A0A3D1YES7 · A0A3D1YES7_9CHLR
- ProteinNADH-quinone oxidoreductase subunit H
- GenenuoH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids370 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Catalytic activity
- a quinone + NADH + 5 H+(in) = a quinol + NAD+ + 4 H+(out)
CHEBI:132124 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= CHEBI:24646 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | NADH dehydrogenase activity | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
Molecular Function | quinone binding | |
Biological Process | aerobic respiration |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-quinone oxidoreductase subunit H
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Chloroflexota > Dehalococcoidia
Accessions
- Primary accessionA0A3D1YES7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-36 | Helical | ||||
Sequence: GITRLMDLLILFSFLAVIVLSLVWL | ||||||
Transmembrane | 82-105 | Helical | ||||
Sequence: VIFWMAPIIVVISSFMLWVTIPFT | ||||||
Transmembrane | 117-137 | Helical | ||||
Sequence: GLFYIGAVGVLGILGLVLAGW | ||||||
Transmembrane | 158-176 | Helical | ||||
Sequence: YEIPLIMILVSIAILTQTF | ||||||
Transmembrane | 188-207 | Helical | ||||
Sequence: VPFALIHPLALVVFFVAGLA | ||||||
Transmembrane | 244-263 | Helical | ||||
Sequence: YINTFAIATLTVLLFLGGWA | ||||||
Transmembrane | 269-287 | Helical | ||||
Sequence: GIVWLLLKVYIVILVIFWI | ||||||
Transmembrane | 299-320 | Helical | ||||
Sequence: LMAFAWKVMVPLSFYSVLVSAV | ||||||
Transmembrane | 326-347 | Helical | ||||
Sequence: FPWWVLSIMSIVGLGVVGYVIY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
Structure
Sequence
- Sequence statusComplete
- Length370
- Mass (Da)41,025
- Last updated2019-01-16 v1
- Checksum5B0DF1EC151D9B8B