A0A396S4A7 · A0A396S4A7_9SPHN
- ProteinAconitate hydratase
- GeneacnA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids889 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Catalytic activity
- (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O
Cofactor
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Organic acid metabolism; propanoate degradation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 2-methylisocitrate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | aconitate hydratase activity | |
Molecular Function | iron-responsive element binding | |
Molecular Function | metal ion binding | |
Biological Process | citrate metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAconitate hydratase
- EC number
- Short namesAconitase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas
Accessions
- Primary accessionA0A396S4A7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 71-561 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: WQQERRSDREIQYRPARVLMQDFTGVPCVVDLAAMRDAITSLGGDAAKINPQVPVHLVIDHSVMVDEFGTPRAFEDNVELEYQRNGERYEFLKWGSKALDNFKVVPPGTGICHQVNLENIAQSVWTSTAADGATIAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPEVVGFKLTGALAEGITATDLVLTVTQMLRAKGVVGRFVEFYGPGMAALSLADRATIANMAPEYGATCGFFPVDAKTIDYMRLTGRDEETLALVEAYCKAQGLWADPNVEPVFTDTLKLDMSSVQPSLAGPKRPQDKVSLSKVDEVFNGDLTKLYKKEAPARVPVSGREHDIGDGDVVIAAITSCTNTSNPSVLIAAGLVARKAVALGLKPKPWVKTSLAPGSQVVTDYLDKAGLTADLNAIGFNLVGYGCTTCIGNSGPLAEPISNAINGNDIVAASVLSGNRNFEGRVSADVRANFLASPPLVVAYALKG | ||||||
Domain | 691-816 | Aconitase A/isopropylmalate dehydratase small subunit swivel | ||||
Sequence: TFLQEHQVSRADFNSYGARRGNHNVMMRGTFANIRIKNEMVPGVEGGMTSYKGETMPIYDAAMRHKADGTPLIVIAGKEYGTGSSRDWAAKGTNLLGVRAVITESFERIHRSNLVGMGVLPLQFAD |
Sequence similarities
Belongs to the aconitase/IPM isomerase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length889
- Mass (Da)95,708
- Last updated2018-12-05 v1
- Checksum92398646A464B828
Keywords
- Technical term