A0A383Z9Y2 · A0A383Z9Y2_BALAS

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

Catalytic activity

Features

Showing features for active site.

119820406080100120140160180
TypeIDPosition(s)Description
Active site51Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionthioredoxin peroxidase activity
Biological Processcell redox homeostasis
Biological Processhydrogen peroxide catabolic process
Biological Processleukocyte activation
Biological Processremoval of superoxide radicals

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-2
  • EC number
  • Alternative names
    • Thioredoxin-dependent peroxiredoxin 2

Gene names

    • Name
      PRDX2

Organism names

Accessions

  • Primary accession
    A0A383Z9Y2

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. Interacts with TIPIN.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-164Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,987
  • Last updated
    2018-11-07 v1
  • Checksum
    E474E12FB9D98869
MTSGNAHIGKPAPEFQATAVVDGAFKEVKLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSERAEEFHKLNCDVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRSLSRDYGVLKEDEGIAYRGLFIIDGKGVLRQITINDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWMPGSDTIKPNVDDSKEYFSKHN

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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