A0A383Z9Y2 · A0A383Z9Y2_BALAS
- ProteinPeroxiredoxin-2
- GenePRDX2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids198 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.
Catalytic activity
- a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O
CHEBI:35924 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3= CHEBI:30879 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 51 | Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | thioredoxin peroxidase activity | |
Biological Process | cell redox homeostasis | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | leukocyte activation | |
Biological Process | removal of superoxide radicals |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxiredoxin-2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Mysticeti > Balaenopteridae > Balaenoptera
Accessions
- Primary accessionA0A383Z9Y2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. Interacts with TIPIN.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-164 | Thioredoxin | ||||
Sequence: AHIGKPAPEFQATAVVDGAFKEVKLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSERAEEFHKLNCDVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRSLSRDYGVLKEDEGIAYRGLFIIDGKGVLRQITINDLPVGRSVDEALRLVQAFQY |
Sequence similarities
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length198
- Mass (Da)21,987
- Last updated2018-11-07 v1
- ChecksumE474E12FB9D98869
Keywords
- Technical term