A0A2Z4SWU2 · A0A2Z4SWU2_ACISI

Function

function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site151Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionaromatase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Biological Processfemale gonad development
Biological Processresponse to estradiol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    aromatase
  • EC number
  • Alternative names
    • Cytochrome P-450AROM
    • Estrogen synthase

Gene names

    • Name
      CYP19A1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Chondrostei > Acipenseriformes > Acipenseridae > Acipenser

Accessions

  • Primary accession
    A0A2Z4SWU2

Subcellular Location

Membrane
; Peripheral membrane protein

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    185
  • Mass (Da)
    21,190
  • Last updated
    2018-10-10 v1
  • Checksum
    DC87877F37DA153D
SHGELSADNVKQCVLEMLIAAPDTMSVTLFYMLMLIAQHPEVERKLLEEIDTVIGENEIQNRDLQNLKVLENFINESLRFHPVVEFSMRRAIEDDVIEGYTVRKGTNIILNMGWMHKGDFFLKPNEFSLDNFHKTVPSRFFQPFGSGPRSCIGKHAALVMMKVILVTLLKRYTVQLQTGCSLKTM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue185

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF631003
EMBL· GenBank· DDBJ
AWY62805.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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