A0A2Z4SWU2 · A0A2Z4SWU2_ACISI
- Proteinaromatase
- GeneCYP19A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids185 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity
- 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Biological Process | female gonad development | |
Biological Process | response to estradiol |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namearomatase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Chondrostei > Acipenseriformes > Acipenseridae > Acipenser
Accessions
- Primary accessionA0A2Z4SWU2
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Structure
Sequence
- Sequence statusFragment
- Length185
- Mass (Da)21,190
- Last updated2018-10-10 v1
- ChecksumDC87877F37DA153D
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 185 | |||||
Sequence: M |