A0A2X0LNV1 · A0A2X0LNV1_9BASI
- ProteinJmjC domain-containing histone demethylation protein 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1167 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.
Catalytic activity
- 2 2-oxoglutarate + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl36-[histone H3] + 2 succinate
2 CHEBI:16810 + RHEA-COMP:9787 CHEBI:61976 Position: 36+ 2 CHEBI:15379 = 2 CHEBI:16526 + 2 CHEBI:16842 + RHEA-COMP:9785 CHEBI:29969 Position: 36+ 2 CHEBI:30031
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone H3K36me/H3K36me2 demethylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription coregulator activity | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameJmjC domain-containing histone demethylation protein 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Pucciniomycotina > Microbotryomycetes > Microbotryales > Microbotryaceae > Microbotryum
Accessions
- Primary accessionA0A2X0LNV1
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-175 | Disordered | ||||
Sequence: MSPTPPPVAAAAAAAAAATMDERDSSPLSTLSELDAASPPVPVPAPSSPATTSAVGPSATGTSATTSAKTSATTSSSSSSSSSTTRLTRSHSHSPSQPSRTPPPSAAAATNEPCRRSSLRSSTCTPIPAPTPATSQPATAVPRLPRLPRLPKVPSRQGTASIRRSERERRDKQRG | ||||||
Compositional bias | 48-96 | Polar residues | ||||
Sequence: SPATTSAVGPSATGTSATTSAKTSATTSSSSSSSSSTTRLTRSHSHSPS | ||||||
Compositional bias | 103-129 | Polar residues | ||||
Sequence: PPSAAAATNEPCRRSSLRSSTCTPIPA | ||||||
Compositional bias | 161-175 | Basic and acidic residues | ||||
Sequence: SIRRSERERRDKQRG | ||||||
Domain | 385-549 | JmjC | ||||
Sequence: VGSTPFGEKIVAPEMVRRLDWVDNIWPKDCRDEGQYPQVQKYCLMSVAESWTIPIHQDWHIDFAGSSVFYHILRGGKVFYFIRPTKENLKAYETWSGNTDRQEANWLGDHVDAVYRVELVPGNTMFIPSGWIHAVETPSDSLVIGGNFVHSLNIETQLEVYRIEL | ||||||
Region | 740-759 | Disordered | ||||
Sequence: MDPHASGTRSKKPRITPSGM | ||||||
Region | 1019-1140 | Disordered | ||||
Sequence: KEGRGTEGDSGTRRKAHGSQSKPRTSSGKMGVAFKNATQPQGPTSVPTSSLTSASTAASTSASTSASTSASTSASGSTSQAPVLETGPAATSPSLQRPDSGDVPMTSPQLKSTQPITSSPVP | ||||||
Compositional bias | 1020-1034 | Basic and acidic residues | ||||
Sequence: EGRGTEGDSGTRRKA | ||||||
Compositional bias | 1039-1140 | Polar residues | ||||
Sequence: SKPRTSSGKMGVAFKNATQPQGPTSVPTSSLTSASTAASTSASTSASTSASTSASGSTSQAPVLETGPAATSPSLQRPDSGDVPMTSPQLKSTQPITSSPVP |
Sequence similarities
Belongs to the JHDM1 histone demethylase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,167
- Mass (Da)127,147
- Last updated2018-09-12 v1
- ChecksumFF2B82F7CA119684
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 48-96 | Polar residues | ||||
Sequence: SPATTSAVGPSATGTSATTSAKTSATTSSSSSSSSSTTRLTRSHSHSPS | ||||||
Compositional bias | 103-129 | Polar residues | ||||
Sequence: PPSAAAATNEPCRRSSLRSSTCTPIPA | ||||||
Compositional bias | 161-175 | Basic and acidic residues | ||||
Sequence: SIRRSERERRDKQRG | ||||||
Compositional bias | 1020-1034 | Basic and acidic residues | ||||
Sequence: EGRGTEGDSGTRRKA | ||||||
Compositional bias | 1039-1140 | Polar residues | ||||
Sequence: SKPRTSSGKMGVAFKNATQPQGPTSVPTSSLTSASTAASTSASTSASTSASTSASGSTSQAPVLETGPAATSPSLQRPDSGDVPMTSPQLKSTQPITSSPVP |
Keywords
- Technical term