A0A2W6XSY0 · A0A2W6XSY0_9FLAO

  • Protein
    Ketol-acid reductoisomerase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.

Features

Showing features for binding site.

147450100150200250300350400450
TypeIDPosition(s)Description
Binding site217Mg2+ 2 (UniProtKB | ChEBI)
Binding site217Mg2+ 1 (UniProtKB | ChEBI)
Binding site221Mg2+ 1 (UniProtKB | ChEBI)
Binding site278substrate
Binding site389Mg2+ 2 (UniProtKB | ChEBI)
Binding site393Mg2+ 2 (UniProtKB | ChEBI)
Binding site414substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Functionisomerase activity
Molecular Functionketol-acid reductoisomerase activity
Molecular Functionmetal ion binding
Biological Processisoleucine biosynthetic process
Biological Processvaline biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ketol-acid reductoisomerase
  • EC number

Gene names

    • ORF names
      DI529_17130

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S2_003_000_R2_7
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Weeksellaceae > Chryseobacterium group > Chryseobacterium

Accessions

  • Primary accession
    A0A2W6XSY0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-208KARI N-terminal Rossmann
Domain209-353KARI C-terminal knotted
Domain354-474KARI C-terminal knotted

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    474
  • Mass (Da)
    52,286
  • Last updated
    2018-09-12 v1
  • Checksum
    A2FD01B033292CA4
MANYFNTLSLRDQLHQLGQAEFMDSSEFSDGVSALKGKKIVVVGCGAQGLNQGLNLRDSGLDVSYALRQEAIDQKRDSWKNATENNFKVGTYEELIPTADLVINLTPDKQHTSVINAVQPLMKQGATLSYSHGFNIVEEGMQIRKDLTVIMVAPKCPGSEVRAEYLRGFGVPTLIAVHPENDPQGKGWAEAKAYCVGTGGHKAGVLKSSFVAEVKSDLMGEQTILCGLLQTGSILSFDKMVEKGIDAGYASKLVQYGVEVITEALKHGGVSGMLDRLSNPAKLKAFELSEELKDIMRPLFQKHQDDIISGEFSKTMMEDWANGDANLLKWRAETGETAFEKTPAGDVKIEEQEYFDNYLLMSAFIRAGVELAFETMVEAGIKPESAYYESLHETPLIANTIARKKLFEMNRVISDTAEYGCYLFDQACKPLLADFMKSVDTDLVGKNFNEGKKTSVDNAQLVYVNDVLRNHPVE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue474

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
QFQW01000119
EMBL· GenBank· DDBJ
PZU79896.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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