A0A2V2WCU4 · A0A2V2WCU4_TRYCR
- ProteinPhosphomannomutase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids245 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Catalytic activity
- alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Cofactor
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 9 | Nucleophile | ||||
Sequence: D | ||||||
Binding site | 9 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 11 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 11 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 18 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 121 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 132 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 139 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 177 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 179 | alpha-D-mannose 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 206 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 218 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 220 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | metal ion binding | |
Molecular Function | phosphomannomutase activity | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | mannose metabolic process | |
Biological Process | protein N-linked glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomannomutase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma > Schizotrypanum
Accessions
- Primary accessionA0A2V2WCU4
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length245
- Mass (Da)28,229
- Last updated2018-09-12 v1
- ChecksumCD8EABF307F1806D