A0A2U9CPN6 · A0A2U9CPN6_SCOMX
- ProteinCleavage and polyadenylation specificity factor subunit 4
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids196 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mRNA cleavage and polyadenylation specificity factor complex | |
Molecular Function | metal ion binding | |
Molecular Function | RNA binding | |
Biological Process | mRNA 3'-end processing |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCleavage and polyadenylation specificity factor subunit 4
- Short namesCPSF 30 kDa subunit
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Carangaria > Pleuronectiformes > Pleuronectoidei > Scophthalmidae > Scophthalmus
Accessions
- Primary accessionA0A2U9CPN6
Proteomes
Subcellular Location
Interaction
Subunit
Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 35-59 | C3H1-type | ||||
Sequence: KSGSAVCEFFMRAACIKGGMCPFRH | ||||||
Zinc finger | 35-59 | C3H1-type | ||||
Sequence: KSGSAVCEFFMRAACIKGGMCPFRH | ||||||
Domain | 62-89 | C3H1-type | ||||
Sequence: GEKTVVCKHWLRGLCKKGDQCEFLHEYD | ||||||
Zinc finger | 62-89 | C3H1-type | ||||
Sequence: GEKTVVCKHWLRGLCKKGDQCEFLHEYD | ||||||
Domain | 90-117 | C3H1-type | ||||
Sequence: MTKMPECYFYSKFGECSNKECPFLHIDP | ||||||
Zinc finger | 90-117 | C3H1-type | ||||
Sequence: MTKMPECYFYSKFGECSNKECPFLHIDP | ||||||
Domain | 118-145 | C3H1-type | ||||
Sequence: ESKIKDCPWYDRGFCKHGPDCRHRHTRR | ||||||
Zinc finger | 118-145 | C3H1-type | ||||
Sequence: ESKIKDCPWYDRGFCKHGPDCRHRHTRR | ||||||
Domain | 147-169 | C3H1-type | ||||
Sequence: ICMNYLVGFCPEGKSCKFMHPRF | ||||||
Zinc finger | 147-169 | C3H1-type | ||||
Sequence: ICMNYLVGFCPEGKSCKFMHPRF | ||||||
Region | 175-196 | Disordered | ||||
Sequence: ASEQPPLQQQAQNQIKPLCSTG | ||||||
Compositional bias | 177-196 | Polar residues | ||||
Sequence: EQPPLQQQAQNQIKPLCSTG |
Sequence similarities
Belongs to the CPSF4/YTH1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length196
- Mass (Da)22,421
- Last updated2018-09-12 v1
- ChecksumADEF9DD9211AF1E2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2U9CPV8 | A0A2U9CPV8_SCOMX | cpsf4 | 266 | ||
A0A2U9CSE1 | A0A2U9CSE1_SCOMX | SMAX5B_006601 | 213 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 177-196 | Polar residues | ||||
Sequence: EQPPLQQQAQNQIKPLCSTG |
Keywords
- Technical term