A0A2N2N0J3 · A0A2N2N0J3_9CHLR
- ProteinMethionine--tRNA ligase
- GenemetG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids600 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Catalytic activity
- tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | methionine-tRNA ligase activity | |
Biological Process | methionyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethionine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Chloroflexota
Accessions
- Primary accessionA0A2N2N0J3
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-418 | Methionyl/Leucyl tRNA synthetase | ||||
Sequence: ILVSAAWPYANAEIHVGNLTGSYLPADIFARYQRLKGNQVLMVSGSDSHGTPITVRADAEGTTPLAVYERFHEGFIDLFQQLGLNYDLFTSTHTQNHQKISQSVFLALKKNGYLYTESQMQWYAPSQSRFLPDRYVEGTCYICGYEGARSDQCDKCGNLLEAEKLINPKSKIDNSTPELRSTEHFYIDLAKLQNHVVDFLKIRDSYWRPNVMRQSLGQILADSLHGRAITRDLDWGIPLPEEVMEVGKEWESKRLYVWFEAVIGYLSASIEWGQLAGNPDAWRNWWQNSESRTYYFIGKDNIPFHAVIWPAELIGAGKAFDEVMGAANPQPLVLPYDVPANEFMNLEGQKISGSRNWGVWGRDFLTRYDPDALRYYLTVNMPESKDTDWDWDEFYHRNNDELVATWGNLANRVL | ||||||
Motif | 12-22 | 'HIGH' region | ||||
Sequence: PYANAEIHVGN | ||||||
Domain | 429-545 | Methionyl-tRNA synthetase anticodon-binding | ||||
Sequence: VPDPGELTELDNDLLKTIEGGFETVGDLIDTVKLRAAAAEAMRLASEVNKYLDVTAPWQQVKTDKATAARAIFTALKAIDSLKILFAPFLPFTSDKLHGFMGYDGSLFGTQTTETLK |
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length600
- Mass (Da)68,012
- Last updated2018-04-25 v1
- ChecksumBBD2B4DA299427DB