A0A2K6QYP2 · A0A2K6QYP2_RHIRO

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site11-16FMN (UniProtKB | ChEBI)
Binding site63-66FMN (UniProtKB | ChEBI)
Binding site98-107FMN (UniProtKB | ChEBI)
Binding site133FMN (UniProtKB | ChEBI)
Binding site223NADP+ (UniProtKB | ChEBI)
Binding site349FAD (UniProtKB | ChEBI)
Binding site379-382FAD (UniProtKB | ChEBI)
Binding site397-399FAD (UniProtKB | ChEBI)
Binding site403FAD (UniProtKB | ChEBI)
Binding site413-416FAD (UniProtKB | ChEBI)
Binding site460NADP+ (UniProtKB | ChEBI)
Binding site521-522NADP+ (UniProtKB | ChEBI)
Binding site527-531NADP+ (UniProtKB | ChEBI)
Binding site563NADP+ (UniProtKB | ChEBI)
Binding site601FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processresponse to hormone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      POR

Organism names

Accessions

  • Primary accession
    A0A2K6QYP2

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-149Flavodoxin-like
Domain204-446FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    602
  • Mass (Da)
    68,191
  • Last updated
    2018-03-28 v1
  • Checksum
    8DF9F67352474018
MKKNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYVGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVIMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHVCAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKRDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYVKKLMTKGRYSLDVWS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K6QYM7A0A2K6QYM7_RHIROPOR680
A0A2K6QYQ3A0A2K6QYQ3_RHIROPOR364
A0A2K6QYN1A0A2K6QYN1_RHIROPOR326
A0A2K6QYQ4A0A2K6QYQ4_RHIROPOR223

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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