A0A2K6AAA5 · A0A2K6AAA5_MANLE
- Proteinthioredoxin-disulfide reductase
- GeneTXNRD3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids561 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- [thioredoxin]-dithiol + NADP+ = [thioredoxin]-disulfide + NADPH + H+This reaction proceeds in the backward direction.
RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:58349 = RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:57783 + CHEBI:15378
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 131 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 195 | FAD (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 260-267 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GASYVALE | ||||||
Binding site | 355 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 397 | FAD (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 535 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Cellular Component | nucleoplasm | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | glutathione-disulfide reductase (NADPH) activity | |
Molecular Function | thioredoxin-disulfide reductase (NADPH) activity | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namethioredoxin-disulfide reductase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Mandrillus
Accessions
- Primary accessionA0A2K6AAA5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 122↔127 | Redox-active | ||||
Sequence: CVNVGC |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-49 | Glutaredoxin | ||||
Sequence: VKELFSSLGVECNVLELDQVDDGAKVQEVLSEITNQKTVPNVFVNKVHV | ||||||
Domain | 76-413 | FAD/NAD(P)-binding | ||||
Sequence: YDLIIVGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVKHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMIQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKMGLEKIGVKINEKSGKIPVNDVEQTSVPYVYAVGDISEGKPELTPVAIQSG | ||||||
Domain | 433-544 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | ||||
Sequence: VPTTVFTPLEYGCCGLAEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKLDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTT |
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length561
- Mass (Da)61,426
- Last updated2018-03-28 v1
- Checksum7A3460024CB18CD4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K6AA85 | A0A2K6AA85_MANLE | TXNRD3 | 525 |
Keywords
- Coding sequence diversity
- Technical term