A0A2K6AAA5 · A0A2K6AAA5_MANLE

Function

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site131FAD (UniProtKB | ChEBI)
Binding site195FAD (UniProtKB | ChEBI)
Binding site260-267NAD+ (UniProtKB | ChEBI)
Binding site355NAD+ (UniProtKB | ChEBI)
Binding site397FAD (UniProtKB | ChEBI)
Active site535Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentnucleoplasm
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Molecular Functionthioredoxin-disulfide reductase (NADPH) activity
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    thioredoxin-disulfide reductase
  • EC number

Gene names

    • Name
      TXNRD3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Mandrillus

Accessions

  • Primary accession
    A0A2K6AAA5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond122↔127Redox-active

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-49Glutaredoxin
Domain76-413FAD/NAD(P)-binding
Domain433-544Pyridine nucleotide-disulphide oxidoreductase dimerisation

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    561
  • Mass (Da)
    61,426
  • Last updated
    2018-03-28 v1
  • Checksum
    7A3460024CB18CD4
VKELFSSLGVECNVLELDQVDDGAKVQEVLSEITNQKTVPNVFVNKVHVGGCDQTFQAYQSGLLQKLLQEDSAYDYDLIIVGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVKHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMIQQLEKGSPGKLKVLAKSTEGTETIEGVYNTVLLAIGRDSCTRKMGLEKIGVKINEKSGKIPVNDVEQTSVPYVYAVGDISEGKPELTPVAIQSGKLLARRLFGASLEKCDYINVPTTVFTPLEYGCCGLAEEKAIEVYKKENLEIYHTLFWPLEWTVAGRENNTCYAKIICNKLDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2K6AA85A0A2K6AA85_MANLETXNRD3525

Keywords

Genome annotation databases

Similar Proteins

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