A0A2K5UN84 · A0A2K5UN84_MACFA
- ProteinProtein tyrosine phosphatase receptor type N
- GenePTPRN
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids924 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | secretory granule | |
Cellular Component | synapse | |
Cellular Component | transport vesicle membrane | |
Molecular Function | protein tyrosine phosphatase activity |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca
Accessions
- Primary accessionA0A2K5UN84
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 522-545 | Helical | ||||
Sequence: VLLTLVALAGVAGLLVALAVALCV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-33 | |||||
Sequence: MRRPRRLGVSGIRGLRLLLCLLLLSSRPGGCSA | ||||||
Chain | PRO_5030051052 | 34-924 | ||||
Sequence: VSAHGCLFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPRRPGPAGELLLQDIPTGSAPASQHRLPQPPVGRGGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPALSYEPALLQPYLFHQFGSRDGSRVSEGSPGMELPAPSRARVPRLPEQGGSSQAEDSPEGYEEEGLGGHGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNLGGAVNVGADIKKTMEGPVEGRDTAEPPARTPPMPAHPTASPTSSEVQQVPSPVSSEPPEAARPAATSVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQREEAAAVLPRIAHSTSPLRSVLLTLVALAGVAGLLVALAVALCVRQHARQRDKERLAALGPEGAHGDTTFEYQDLCRQHMAAKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTLETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 111-172 | Disordered | ||||
Sequence: RIPRLRPPEPRPRDRSGLAPRRPGPAGELLLQDIPTGSAPASQHRLPQPPVGRGGAGASSSL | ||||||
Compositional bias | 112-128 | Basic and acidic residues | ||||
Sequence: IPRLRPPEPRPRDRSGL | ||||||
Region | 215-273 | Disordered | ||||
Sequence: SRDGSRVSEGSPGMELPAPSRARVPRLPEQGGSSQAEDSPEGYEEEGLGGHGEKPASPA | ||||||
Region | 332-385 | Disordered | ||||
Sequence: KTMEGPVEGRDTAEPPARTPPMPAHPTASPTSSEVQQVPSPVSSEPPEAARPAA | ||||||
Compositional bias | 359-374 | Polar residues | ||||
Sequence: ASPTSSEVQQVPSPVS | ||||||
Region | 588-625 | Disordered | ||||
Sequence: NRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCE | ||||||
Compositional bias | 597-625 | Polar residues | ||||
Sequence: SRVSSVSSQFSDAAQASPSSHSSTPSWCE | ||||||
Domain | 654-914 | Tyrosine-protein phosphatase | ||||
Sequence: LAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTLETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE | ||||||
Domain | 833-905 | Tyrosine specific protein phosphatases | ||||
Sequence: LDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFE |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length924
- Mass (Da)100,261
- Last updated2021-06-02 v2
- Checksum53117068A06CF12F
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5UNC8 | A0A2K5UNC8_MACFA | PTPRN | 1056 | ||
A0A7N9IFK6 | A0A7N9IFK6_MACFA | PTPRN | 905 | ||
A0A7N9CGS8 | A0A7N9CGS8_MACFA | PTPRN | 952 | ||
A0A7N9CDV9 | A0A7N9CDV9_MACFA | PTPRN | 978 | ||
A0A2K5UNB7 | A0A2K5UNB7_MACFA | PTPRN | 961 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 112-128 | Basic and acidic residues | ||||
Sequence: IPRLRPPEPRPRDRSGL | ||||||
Compositional bias | 359-374 | Polar residues | ||||
Sequence: ASPTSSEVQQVPSPVS | ||||||
Compositional bias | 597-625 | Polar residues | ||||
Sequence: SRVSSVSSQFSDAAQASPSSHSSTPSWCE |
Keywords
- Technical term