A0A2K5MWP9 · A0A2K5MWP9_CERAT
- ProteinNeuregulin 1
- GeneNRG1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids296 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | chemorepellent activity | |
Molecular Function | growth factor activity | |
Molecular Function | protein tyrosine kinase activator activity | |
Biological Process | activation of transmembrane receptor protein tyrosine kinase activity | |
Biological Process | animal organ development | |
Biological Process | cell differentiation | |
Biological Process | intracellular signal transduction | |
Biological Process | nervous system development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Cercocebus
Accessions
- Primary accessionA0A2K5MWP9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 76-99 | Helical | ||||
Sequence: ICIVPILACLVSLCLCIAGLKWVF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 267↔276 | |||||
Sequence: CPNEFTGDRC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-48 | Disordered | ||||
Sequence: MEIYSPDMSEVAAERSSSPSTQLSADPSLDGLPAAEDMPEPQTEDGRT | ||||||
Compositional bias | 11-27 | Polar residues | ||||
Sequence: VAAERSSSPSTQLSADP | ||||||
Region | 189-228 | Disordered | ||||
Sequence: PSFPSPTRNPEVRTPKSATQPQTTETNLQTAPKLSTSTST | ||||||
Domain | 233-277 | EGF-like | ||||
Sequence: HLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQ |
Sequence similarities
Belongs to the neuregulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length296
- Mass (Da)31,739
- Last updated2018-03-28 v1
- Checksum5673AE42AEF9F2B3
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2K5MWN5 | A0A2K5MWN5_CERAT | NRG1 | 640 | ||
A0A2K5MWZ4 | A0A2K5MWZ4_CERAT | NRG1 | 599 | ||
A0A2K5MWJ6 | A0A2K5MWJ6_CERAT | NRG1 | 606 | ||
A0A2K5MWJ7 | A0A2K5MWJ7_CERAT | NRG1 | 308 | ||
A0A2K5MWK1 | A0A2K5MWK1_CERAT | NRG1 | 462 | ||
A0A2K5MWK3 | A0A2K5MWK3_CERAT | NRG1 | 253 | ||
A0A2K5MWM6 | A0A2K5MWM6_CERAT | NRG1 | 713 | ||
A0A2K5MWH5 | A0A2K5MWH5_CERAT | NRG1 | 590 | ||
A0A2K5MWJ1 | A0A2K5MWJ1_CERAT | NRG1 | 637 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-27 | Polar residues | ||||
Sequence: VAAERSSSPSTQLSADP |
Keywords
- Technical term