A0A2I0PM52 · A0A2I0PM52_9EURY
- ProteinArchaetidylinositol phosphate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids188 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
Catalytic activity
- 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H+ + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate
Cofactor
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Binds 2 Mg2+ or Mn2+ ions per subunit.
Pathway
Lipid metabolism; phospholipid metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 61 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 61 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 64 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 82 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 82 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 86 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 86 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphotransferase activity, for other substituted phosphate groups | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArchaetidylinositol phosphate synthase
- EC number
- Short namesAIP synthase
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales
Accessions
- Primary accessionA0A2I0PM52
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-41 | Helical | ||||
Sequence: ININPNYLTVLGLLIALLSAYM | ||||||
Transmembrane | 47-67 | Helical | ||||
Sequence: LLWGGLFIALSGFLDIIDGAV | ||||||
Transmembrane | 88-112 | Helical | ||||
Sequence: FSDAIIIIGIIYGGFVNWIFGILAL | ||||||
Transmembrane | 160-181 | Helical | ||||
Sequence: IMSAAIILIIVLGYFTVLQRVY |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length188
- Mass (Da)20,548
- Last updated2018-02-28 v1
- ChecksumB72DD3C45AF3D9F1