A0A2I0PM52 · A0A2I0PM52_9EURY

Function

function

Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ or Mn2+ ions per subunit.

Pathway

Lipid metabolism; phospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site61Mg2+ 2 (UniProtKB | ChEBI)
Binding site61Mg2+ 1 (UniProtKB | ChEBI)
Binding site64Mg2+ 1 (UniProtKB | ChEBI)
Binding site82Mg2+ 2 (UniProtKB | ChEBI)
Binding site82Mg2+ 1 (UniProtKB | ChEBI)
Active site86Proton acceptor
Binding site86Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Archaetidylinositol phosphate synthase
  • EC number
  • Short names
    AIP synthase

Gene names

    • ORF names
      CVV28_05645

Organism names

Accessions

  • Primary accession
    A0A2I0PM52

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-41Helical
Transmembrane47-67Helical
Transmembrane88-112Helical
Transmembrane160-181Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    20,548
  • Last updated
    2018-02-28 v1
  • Checksum
    B72DD3C45AF3D9F1
MLNRLRPSIKKFIDPLAKIININPNYLTVLGLLIALLSAYMFAMGNLLWGGLFIALSGFLDIIDGAVARNNNTTTKFGGFLDSTTDRFSDAIIIIGIIYGGFVNWIFGILALHASLSVSYVRARAEVEGIPCGVGIAERAERMVILMAGAFLGALFSPKIMSAAIILIIVLGYFTVLQRVYHTWKSMK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PGYO01000004
EMBL· GenBank· DDBJ
PKL67349.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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