A0A2A6VYJ1 · A0A2A6VYJ1_HELPX

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site56-60(6S)-NADPHX (UniProtKB | ChEBI)
Binding site57K+ (UniProtKB | ChEBI)
Binding site118K+ (UniProtKB | ChEBI)
Binding site149(6S)-NADPHX (UniProtKB | ChEBI)
Binding site152K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • Name
      nnrE
    • ORF names
      B0X61_06075

Organism names

Accessions

  • Primary accession
    A0A2A6VYJ1

Proteomes

Family & Domains

Sequence similarities

Belongs to the NnrE/AIBP family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    50,495
  • Last updated
    2017-12-20 v1
  • Checksum
    BDB9D17E8F09D93F
MLSVYEKVNALDKRAIEEWLLSEDILMENAAMALERAVLQNASLGAKVIILCGSGDNGGDGYALARRLVGRFRVLVFEMKLAKSPMCQLQKERAKKAGVVIKTYEEKNEDLECDVLIDCVVGSAFKGGLEPFLNFESLSQKARFKIACDIPSGIDSKGRVDKRAFKADMTISMGAIKSCLLSDRAKDYVGELKVGHLGVFNPIYEIPTDTFLLEKSDLKLPLRDKKNAHKGDYGHAHVLLGKHSGAGLLSALSALSFGSGVVSVQALECEITSNNKPLELVFCENFPNPLSAFALGMGLEGLPKDFKKWLGLAPCVLDAGVFYHKEVLQALEKEVILTPHPKEFLSLLKLVGINISMLELLDNKLEIARDFSQKYPKVVLLLKGANTLIAHQGRTFINNLGSVALAKAGSGDVLAGLILSLLSQNYTPLDAAINASLAHALAGLEFKNNYALTPLDLIEKIKRL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MUPD01000120
EMBL· GenBank· DDBJ
OOQ14642.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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