A0A288P050 · A0A288P050_OCHCA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids235 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona
Accessions
- Primary accessionA0A288P050
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYMLFGAWAGMVGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-126 | Helical | ||||
Sequence: LLPPSFLLLLASSMVEAGVGTGW | ||||||
Transmembrane | 146-171 | Helical | ||||
Sequence: AIFSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-235 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFINRWLFSTNHKDIGTLYMLFGAWAGMVGTALSLLIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGVGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length235
- Mass (Da)25,407
- Last updated2017-12-20 v1
- Checksum3D0D7FE820DE4AE3
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 235 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KT805343 EMBL· GenBank· DDBJ | AOD27454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805344 EMBL· GenBank· DDBJ | AOD27455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805345 EMBL· GenBank· DDBJ | AOD27456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805346 EMBL· GenBank· DDBJ | AOD27457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805347 EMBL· GenBank· DDBJ | AOD27458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805349 EMBL· GenBank· DDBJ | AOD27460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805350 EMBL· GenBank· DDBJ | AOD27461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805351 EMBL· GenBank· DDBJ | AOD27462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805352 EMBL· GenBank· DDBJ | AOD27463.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805353 EMBL· GenBank· DDBJ | AOD27464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805354 EMBL· GenBank· DDBJ | AOD27465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805355 EMBL· GenBank· DDBJ | AOD27466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805356 EMBL· GenBank· DDBJ | AOD27467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805357 EMBL· GenBank· DDBJ | AOD27468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805358 EMBL· GenBank· DDBJ | AOD27469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805359 EMBL· GenBank· DDBJ | AOD27470.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805360 EMBL· GenBank· DDBJ | AOD27471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805361 EMBL· GenBank· DDBJ | AOD27472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805362 EMBL· GenBank· DDBJ | AOD27473.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805363 EMBL· GenBank· DDBJ | AOD27474.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT805364 EMBL· GenBank· DDBJ | AOD27475.1 EMBL· GenBank· DDBJ | Genomic DNA |