A0A288P050 · A0A288P050_OCHCA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona

Accessions

  • Primary accession
    A0A288P050

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-126Helical
Transmembrane146-171Helical
Transmembrane183-210Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-235Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    235
  • Mass (Da)
    25,407
  • Last updated
    2017-12-20 v1
  • Checksum
    3D0D7FE820DE4AE3
MFINRWLFSTNHKDIGTLYMLFGAWAGMVGTALSLLIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGVGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue235

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT805343
EMBL· GenBank· DDBJ
AOD27454.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805344
EMBL· GenBank· DDBJ
AOD27455.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805345
EMBL· GenBank· DDBJ
AOD27456.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805346
EMBL· GenBank· DDBJ
AOD27457.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805347
EMBL· GenBank· DDBJ
AOD27458.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805349
EMBL· GenBank· DDBJ
AOD27460.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805350
EMBL· GenBank· DDBJ
AOD27461.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805351
EMBL· GenBank· DDBJ
AOD27462.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805352
EMBL· GenBank· DDBJ
AOD27463.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805353
EMBL· GenBank· DDBJ
AOD27464.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805354
EMBL· GenBank· DDBJ
AOD27465.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805355
EMBL· GenBank· DDBJ
AOD27466.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805356
EMBL· GenBank· DDBJ
AOD27467.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805357
EMBL· GenBank· DDBJ
AOD27468.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805358
EMBL· GenBank· DDBJ
AOD27469.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805359
EMBL· GenBank· DDBJ
AOD27470.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805360
EMBL· GenBank· DDBJ
AOD27471.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805361
EMBL· GenBank· DDBJ
AOD27472.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805362
EMBL· GenBank· DDBJ
AOD27473.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805363
EMBL· GenBank· DDBJ
AOD27474.1
EMBL· GenBank· DDBJ
Genomic DNA
KT805364
EMBL· GenBank· DDBJ
AOD27475.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp