A0A259CSH2 · A0A259CSH2_9PROT
- ProteinBiosynthetic peptidoglycan transglycosylase
- GenemtgA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
Catalytic activity
- [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate RHEA-COMP:9602 + CHEBI:60033 = [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate RHEA-COMP:9603 + CHEBI:58405 + CHEBI:15378
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peptidoglycan-based cell wall | |
Cellular Component | plasma membrane | |
Molecular Function | pentosyltransferase activity | |
Molecular Function | peptidoglycan glycosyltransferase activity | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBiosynthetic peptidoglycan transglycosylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Methylophilaceae
Accessions
- Primary accessionA0A259CSH2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-28 | Helical | ||||
Sequence: VVIFLFAVAYQIWILIHIWWWI |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-219 | Glycosyl transferase family 51 | ||||
Sequence: AELKYKWVDYDKISTHLKRAVIASEDAKFTMHEGFDWEGIEKAYEKNLKKGKIVAGGSTISQQLAKNLFLSSKRTPWRKGQEVIITMMLEKMMTKRRIFEIYLNVIEWGNGVFGAEAAARHYFKTSARGLDKQQSAKLAAMIPNPRFYDKHRMTRYLNKRTRTIQARM |
Sequence similarities
Belongs to the glycosyltransferase 51 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)26,586
- Last updated2017-12-20 v1
- Checksum235693A35388EDD3