A0A243RWL2 · A0A243RWL2_9ACTN

Function

function

Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.

Features

Showing features for binding site.

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MWITDWTSRAACKGADPDALFVQGAAQNRAKLICRGCPVRTECLADALDNRIEFGVWGGMTERERRALLRRRPDVDSWRDLLELAKEEYERTNELIAG
TypeIDPosition(s)Description
Binding site12[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site34[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site37[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site43[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functiondinitrosyl-iron complex binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionprotein-disulfide reductase (NAD(P)H) activity
Biological Processcell redox homeostasis
Biological Processnegative regulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulator WhiB

Gene names

    • Name
      whiB
    • ORF names
      CA984_02425

Organism names

  • Taxonomic identifier
  • Strain
    • M26
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Streptosporangiaceae > Streptosporangium

Accessions

  • Primary accession
    A0A243RWL2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Post-translational modification

The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-674Fe-4S Wbl-type

Sequence similarities

Belongs to the WhiB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    98
  • Mass (Da)
    11,196
  • Last updated
    2017-10-25 v1
  • Checksum
    AFA3172FB1648086
MWITDWTSRAACKGADPDALFVQGAAQNRAKLICRGCPVRTECLADALDNRIEFGVWGGMTERERRALLRRRPDVDSWRDLLELAKEEYERTNELIAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NGFP01000006
EMBL· GenBank· DDBJ
OUC99572.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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