A0A241WQM0 · A0A241WQM0_9GAMM

Function

function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

dipyrromethane (UniProtKB | Rhea| CHEBI:60342 )

Note: Binds 1 dipyrromethane group covalently.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionhydroxymethylbilane synthase activity
Biological Processpeptidyl-pyrromethane cofactor linkage
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Porphobilinogen deaminase
  • EC number
  • Short names
    PBG
  • Alternative names
    • Hydroxymethylbilane synthase
      (HMBS
      )
    • Pre-uroporphyrinogen synthase

Gene names

    • Name
      hemC
    • ORF names
      B9T24_07715

Organism names

  • Taxonomic identifier
  • Strain
    • ANC 4654
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A241WQM0

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue240S-(dipyrrolylmethanemethyl)cysteine

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-210Porphobilinogen deaminase N-terminal
Domain224-293Porphobilinogen deaminase C-terminal

Sequence similarities

Belongs to the HMBS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    32,973
  • Last updated
    2017-10-25 v1
  • Checksum
    B3BDFD56B75BC8FB
MKILKIATRQSPLALWQAEHIRARLEAMHADLQVELVTFVTQGDKILDTPLAKIGGKGLFVKELEEALLDGRADLAVHSMKDVPMALPEGLTLAVICEREDPLDAFVSNTYHSFAELPHGAKVGTSSLRRKCQILKQRPDLEIVDLRGNVGTRLSKLDAGLYDAIILASAGLKRLGLADRIRHTLQVEISLPAVGQGALGLECRAADQAVLDLILPLLHDETDICVRAERAFNAYLEGGCQVPIAGYASLNQGQLHIEGRVGSVDGATLLKVTLKGTPEQAEQLGETLAQKLLEQGAGDLLKAFY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NEGL01000004
EMBL· GenBank· DDBJ
OTG96604.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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