A0A219CM62 · BMN7O_BOMOR

Function

function

Bombinin-like peptide 7

Antimicrobial peptide with activity against Gram-positive and -negative bacteria and fungi (PubMed:22439858, PubMed:32540219).
Shows activity against P.acnes (MIC=5 uM), E.coli (MIC=5-6.3 uM), S.aureus (MIC=5-6.3 uM), M.luteus, S.cerevisiae and C.albicans (MIC=10-12.5 uM) (PubMed:22439858, PubMed:28636781, PubMed:32540219).
Also reduces the production of interleukin (IL)-8 and granulocyte-macrophage colony stimulating factor (CSF2) in normal human epidermal keratinocytes (NHEKs) (PubMed:32540219).
Shows anticancer activity against three human hepatoma cell lines (PubMed:28636781).
In vivo, using the rat ear edema model, suppress P.acnes-induced skin inflammation, significantly reducing the ear thickness (PubMed:32540219).
Shows weak hemolytic activity against human erythrocytes (PubMed:28636781).

Bombinin H-BO

Shows weak antimicrobial activity (tested on E.coli, S.aureus and C.albicans) (PubMed:28636781).
Shows high hemolytic activity against human erythrocytes (38% erythrocyte lysis at 80.0 uM, and up to 85% at 159.7 uM) (PubMed:28636781).

Miscellaneous

BLP-7 is also encoded by another gene from the same species (AC Q9DET7).

pH Dependence

Stable from pH 3.0 to 12.0.

Temperature Dependence

Highly thermostable, when continuously exposed at the temperatures ranging from 20 to 100 degrees Celsius for 30 minutes.

GO annotations

AspectTerm
Cellular Componentextracellular region
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processkilling of cells of another organism

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    A0A219CM62

Subcellular Location

Keywords

Phenotypes & Variants

Pharmaceutical

Bombinin-like peptide 7

Could be used as a potential agent in the treatment against acne, since it shows antibacterial activity against P.acnes and it both reduces the production of pro-inflammatory cytokines and the skin inflammation induced by P.acnes in rat ear edema model.

PTM/Processing

Features

Showing features for signal, propeptide, peptide, modified residue.

TypeIDPosition(s)Description
Signal1-18
PropeptidePRO_000045108519-43
PeptidePRO_501196792944-70Bombinin-like peptide 7
Modified residue70Asparagine amide
PropeptidePRO_000045108674-123
PeptidePRO_0000451087124-140Bombinin H-BO
Modified residue140Leucine amide

Keywords

Expression

Tissue specificity

Expressed by the skin glands.

Family & Domains

Sequence similarities

Belongs to the bombinin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    141
  • Mass (Da)
    15,454
  • Last updated
    2017-09-27 v1
  • Checksum
    22421C38556AB39C
MNFKYIIAVSFLIASTYARSVKNDEQSLSQRDVLDEESLREIRGIGGALLSAGKSALKGLAKGLAEHFANGKRTAEEHEVMKRLEAVMRDLDSLDHPEEASEKETRGFNQEEIANLFTKKEKRIIGPVLGLIGKALGGLLG

Mass Spectrometry

Bombinin-like peptide 7

Molecular mass is 2,551.01 Da. Determined by Electrospray.

Bombinin H-BO

Molecular mass is 1,603.08 Da. Determined by Electrospray.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LT732574
EMBL· GenBank· DDBJ
SJN60136.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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