A0A218QX55 · A0A218QX55_TITSE

Function

function

Acts as a metalloprotease. Penetrates intact tissue and specifically cleaves the vesicle-associated membrane protein 2 (VAMP2) (part of the SNARE complex) involved in pancreatic secretion, thus disrupting the normal vesicular traffic.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

140150100150200250300350400
TypeIDPosition(s)Description
Binding site324Zn2+ (UniProtKB | ChEBI); catalytic
Active site325
Binding site328Zn2+ (UniProtKB | ChEBI); catalytic
Binding site334Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Putative metalloprotease

Organism names

Accessions

  • Primary accession
    A0A218QX55

Subcellular Location

Secreted

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_501201324117-401

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain169-396Peptidase M12B

Sequence similarities

Belongs to the venom metalloproteinase (M12B) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    401
  • Mass (Da)
    45,174
  • Last updated
    2017-09-27 v1
  • Checksum
    0BB2A80CAC536D22
MLSSLTILLFSTSVLAIPHRRIEVTYPSLETSRSGIKIMKLRVFDQDIALNLEPAGDVISDDFAIMDEQGEIEPVDVKSFKGKLFRDQKKGASLHIDEDGFIEIDGIINSKLRIEPSESQNVGKYGMKEHVIFETFDEKKHFRDIVYNLNLQRSFSKNKAMNLSKDQCVEIEYVFLADKKFRDEYRNLDVFKKNIGSIVIQVQNLLDTLNLNIKIKTLAILIFVVDPPFLKDSLIPCEEMFNVAVILPNFGKYICEKKETGVIAEADIILFLSRREIGYMDEDGEIYKDILGASHLGGACQECKKVGFILWEDDMHYTAVTVAHESAHLIGSPHDSEGGVAQSYPGSPGSEDCPLEDGFILGDNEGENEDKFSTCTIKNVKYFLSQNEASCLITNCKNRVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEUW01000015
EMBL· GenBank· DDBJ
JAW07030.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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