A0A1Y2U4X6 · A0A1Y2U4X6_9PEZI

  • Protein
    Structure-specific endonuclease subunit SLX4
  • Gene
    SLX4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentSlx1-Slx4 complex
Molecular Function5'-flap endonuclease activity
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Structure-specific endonuclease subunit SLX4

Gene names

    • Name
      SLX4
    • ORF names
      K449DRAFT_386771

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • EC38
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Hypoxylaceae > Hypoxylon

Accessions

  • Primary accession
    A0A1Y2U4X6

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Post-translational modification

Phosphorylated in response to DNA damage.

Keywords

Interaction

Subunit

Forms a heterodimer with SLX1.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-57Disordered
Compositional bias16-37Polar residues
Region72-227Disordered
Compositional bias134-149Polar residues
Compositional bias150-167Basic and acidic residues
Region354-390Disordered
Compositional bias514-536Polar residues
Region514-550Disordered
Compositional bias585-615Polar residues
Region585-691Disordered
Compositional bias628-643Polar residues
Compositional bias668-683Polar residues

Sequence similarities

Belongs to the SLX4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    801
  • Mass (Da)
    87,445
  • Last updated
    2017-08-30 v1
  • Checksum
    3CCE6689F4E56B85
MSAADVFLSSPPRPVKINSYALSSSPNLPPLDEIFSNTSKHPSRRSRSHAAAIPDDAPSTFTSAAILLREAPEIDIETEKITHSPPRKSNPSGAGKKKAPTPEAISVPTEATVLIDSSPGDKPWQKFKNKKPTSQGEKQAVQKACITKSNTKGKPREKTETVSRHFAPKESAARYVQKGSDRGKTVLELEDQATSGPSCSEPALRRRSDWTPPPANNPILPELESDNQELLSSIERLPKSKDVFQTLVEDYGRKDTLPCVVSNKLQQVDIITKRKLIELVPTGNEIGQFPRETSPPKIVNAKKKTRTITELATAPYILATEPALDLVGLATKESLLNYFDSDGAVKALVEHQTAVMSQKKEKPKESKPSSKPKRKKKAGTANNPILLSPNSALKQTSNQDFVFGTSSQLVGEESPTTLRDLQLAMQASNQVDSDPFADSDSQGLWHAGARDTDGELMKADEFEIEDLPLPLGLRKQSQYSREEFVDINDVLKSSGVDESAAPAPQPNSHFIESQVVSSAQPPKPEDQGNTESQRAAAASDPRPDFESFSDAQLSRQIASYGFKPVKKRQAMIALLDQCWNSKSSGTSIIQSRSISTSSSVSASKRKQQTATTGPENPPKRRGRPRKNSTAETPSATTSTSKETNLKRPRGRQKKASPKPVEIADSDLDDSVISTSSKASSPDRDRIFSSPPAVDLSISDEVDMSLTLSPTGQQADLFRHITKAVTSAPRSRDPSQPSWHEKMLLYDPIVLEDLAAWLNAGALSGAGYDGEVSPFDVKKWCESKSVICLWRQNLNGKERKRY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias16-37Polar residues
Compositional bias134-149Polar residues
Compositional bias150-167Basic and acidic residues
Compositional bias514-536Polar residues
Compositional bias585-615Polar residues
Compositional bias628-643Polar residues
Compositional bias668-683Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ111237
EMBL· GenBank· DDBJ
OTA68480.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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