A0A1Y2U4X6 · A0A1Y2U4X6_9PEZI
- ProteinStructure-specific endonuclease subunit SLX4
- GeneSLX4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids801 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Slx1-Slx4 complex | |
Molecular Function | 5'-flap endonuclease activity | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameStructure-specific endonuclease subunit SLX4
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales > Hypoxylaceae > Hypoxylon
Accessions
- Primary accessionA0A1Y2U4X6
Proteomes
Subcellular Location
PTM/Processing
Post-translational modification
Phosphorylated in response to DNA damage.
Keywords
- PTM
Interaction
Subunit
Forms a heterodimer with SLX1.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-57 | Disordered | ||||
Sequence: MSAADVFLSSPPRPVKINSYALSSSPNLPPLDEIFSNTSKHPSRRSRSHAAAIPDDA | ||||||
Compositional bias | 16-37 | Polar residues | ||||
Sequence: KINSYALSSSPNLPPLDEIFSN | ||||||
Region | 72-227 | Disordered | ||||
Sequence: PEIDIETEKITHSPPRKSNPSGAGKKKAPTPEAISVPTEATVLIDSSPGDKPWQKFKNKKPTSQGEKQAVQKACITKSNTKGKPREKTETVSRHFAPKESAARYVQKGSDRGKTVLELEDQATSGPSCSEPALRRRSDWTPPPANNPILPELESDN | ||||||
Compositional bias | 134-149 | Polar residues | ||||
Sequence: SQGEKQAVQKACITKS | ||||||
Compositional bias | 150-167 | Basic and acidic residues | ||||
Sequence: NTKGKPREKTETVSRHFA | ||||||
Region | 354-390 | Disordered | ||||
Sequence: AVMSQKKEKPKESKPSSKPKRKKKAGTANNPILLSPN | ||||||
Compositional bias | 514-536 | Polar residues | ||||
Sequence: QVVSSAQPPKPEDQGNTESQRAA | ||||||
Region | 514-550 | Disordered | ||||
Sequence: QVVSSAQPPKPEDQGNTESQRAAAASDPRPDFESFSD | ||||||
Compositional bias | 585-615 | Polar residues | ||||
Sequence: GTSIIQSRSISTSSSVSASKRKQQTATTGPE | ||||||
Region | 585-691 | Disordered | ||||
Sequence: GTSIIQSRSISTSSSVSASKRKQQTATTGPENPPKRRGRPRKNSTAETPSATTSTSKETNLKRPRGRQKKASPKPVEIADSDLDDSVISTSSKASSPDRDRIFSSPP | ||||||
Compositional bias | 628-643 | Polar residues | ||||
Sequence: STAETPSATTSTSKET | ||||||
Compositional bias | 668-683 | Polar residues | ||||
Sequence: DDSVISTSSKASSPDR |
Sequence similarities
Belongs to the SLX4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length801
- Mass (Da)87,445
- Last updated2017-08-30 v1
- Checksum3CCE6689F4E56B85
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 16-37 | Polar residues | ||||
Sequence: KINSYALSSSPNLPPLDEIFSN | ||||||
Compositional bias | 134-149 | Polar residues | ||||
Sequence: SQGEKQAVQKACITKS | ||||||
Compositional bias | 150-167 | Basic and acidic residues | ||||
Sequence: NTKGKPREKTETVSRHFA | ||||||
Compositional bias | 514-536 | Polar residues | ||||
Sequence: QVVSSAQPPKPEDQGNTESQRAA | ||||||
Compositional bias | 585-615 | Polar residues | ||||
Sequence: GTSIIQSRSISTSSSVSASKRKQQTATTGPE | ||||||
Compositional bias | 628-643 | Polar residues | ||||
Sequence: STAETPSATTSTSKET | ||||||
Compositional bias | 668-683 | Polar residues | ||||
Sequence: DDSVISTSSKASSPDR |