A0A1X0J5I4 · A0A1X0J5I4_MYCRH

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site11substrate
Binding site78substrate
Active site87
Active site87Proton donor
Binding site88-89substrate
Binding site163substrate
Site165Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site199substrate
Site217Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site217-218substrate
Active site226Proton acceptor
Binding site227-228substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      BST42_02555

Organism names

Accessions

  • Primary accession
    A0A1X0J5I4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    289
  • Mass (Da)
    30,057
  • Last updated
    2017-07-05 v1
  • Checksum
    1A7BC71F294C871D
MIFSKGHGTENDFVLLPDLPAQLELAPAAVAALCDRRRGLGADGVLRVTTAGAVVDAGVLDRLPEGVDSGDWYMDYRNADGSIAQMCGNGVRVFAHYLRASGLEQRDEFVVGTLAGPRPVVVHRADAVAAEVTVDMGKVNLLGTGTATVGGRHFTGVGVDVGNPHLACLDPDLTEKALADLDVAAPVLFDRGQFPDGVNIEVLTIARDGAVSMRVHERGVGETRSCGTGTVAAAVAALAHLNLSTGTLRVRIPGGEVTVEVSHTSSSLRGPSVLVAHGELADDWWAAQL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MVIH01000001
EMBL· GenBank· DDBJ
ORB57294.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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