A0A1X0J5I4 · A0A1X0J5I4_MYCRH
- ProteinDiaminopimelate epimerase
- GenedapF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids289 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Catalytic activity
- (2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11 | substrate | ||||
Sequence: N | ||||||
Binding site | 78 | substrate | ||||
Sequence: N | ||||||
Active site | 87 | |||||
Sequence: C | ||||||
Active site | 87 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 88-89 | substrate | ||||
Sequence: GN | ||||||
Binding site | 163 | substrate | ||||
Sequence: N | ||||||
Site | 165 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: H | ||||||
Binding site | 199 | substrate | ||||
Sequence: N | ||||||
Site | 217 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: E | ||||||
Binding site | 217-218 | substrate | ||||
Sequence: ER | ||||||
Active site | 226 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 227-228 | substrate | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | diaminopimelate epimerase activity | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate epimerase
- EC number
- Short namesDAP epimerase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A1X0J5I4
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length289
- Mass (Da)30,057
- Last updated2017-07-05 v1
- Checksum1A7BC71F294C871D