A0A1W6K1P7 · A0A1W6K1P7_9CREN

  • Protein
    Probable GTP 3',8-cyclase
  • Gene
    moaA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.

Pathway

Cofactor biosynthesis; molybdopterin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13GTP (UniProtKB | ChEBI)
Binding site20[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site24[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site27[4Fe-4S] cluster 1 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site61GTP (UniProtKB | ChEBI)
Binding site65S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site90GTP (UniProtKB | ChEBI)
Binding site114S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site151GTP (UniProtKB | ChEBI)
Binding site245[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site248[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate
Binding site250-252GTP (UniProtKB | ChEBI)
Binding site262[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-substrate

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionGTP 3',8'-cyclase activity
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionS-adenosyl-L-methionine binding
Biological ProcessMo-molybdopterin cofactor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable GTP 3',8-cyclase
  • EC number
  • Alternative names
    • Molybdenum cofactor biosynthesis protein A

Gene names

    • Name
      moaA
    • ORF names
      B6F84_10815

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • YN-25
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Acidianus

Accessions

  • Primary accession
    A0A1W6K1P7

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-224Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. MoaA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    308
  • Mass (Da)
    35,274
  • Last updated
    2017-07-05 v1
  • Checksum
    AC6C7D2D2D5165FB
MKDRYGRELEDLRITLTHVCNFSCFFCHMEGEGDLYVNGLTPDEIELVAEVSKEYGIKYVKLTGGEPTLRRDLTEIIYRLRNLGLEVSMTTNGYMLSKIASKLKEAGLNRVNISLHTLDKEKFKKITGVDGMDRVIEGIKEAINVGLKPVKLNFVATKMNINEAFNVIDFAEKIGVNELHLIELHPVGMGKIAFSYHEKLNNLENVLKEKALREGTRNKHYRPRFYLPSGLVVEIVKPYANPIFCSGCNRIRLTVDGKLKTCLYRDDNSIEILNILRSNLDKYHKMQLLKEAFDVAIAIREPNFKYII

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP020477
EMBL· GenBank· DDBJ
ARM76463.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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