A0A1W1Y2K7 · A0A1W1Y2K7_9SPHN
- ProteinCatalase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids725 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity
- 2 H2O2 = 2 H2O + O2
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 102 | heme (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 105 | |||||
Sequence: H | ||||||
Binding site | 142 | heme (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 178 | |||||
Sequence: N | ||||||
Binding site | 191 | heme (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 388 | heme (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 392 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: Y | ||||||
Binding site | 399 | heme (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCatalase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Novosphingobium
Accessions
- Primary accessionA0A1W1Y2K7
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Basic and acidic residues | ||||
Sequence: MPKPDKAQRSDKSKQKGETPK | ||||||
Region | 1-79 | Disordered | ||||
Sequence: MPKPDKAQRSDKSKQKGETPKKAPKLPPQSDLPTSYAEPQGNGGETHQTTSDPAATMTSQQGIPISDGQNSLRAGPRGP | ||||||
Compositional bias | 33-68 | Polar residues | ||||
Sequence: PTSYAEPQGNGGETHQTTSDPAATMTSQQGIPISDG | ||||||
Domain | 58-446 | Catalase core | ||||
Sequence: TSQQGIPISDGQNSLRAGPRGPTLLEDFQLREKIFHFDHERIPERVVHARGTGAHGVFELTDSLADYTTADVLSRVGQQTETFVRFSTVAGRAGSFDLARDVRGFAVKLYTAEGNWDLVGNNIPVFFIQDAIKFPDLVHAVKEEPDRGFPQAQSAHDNFWDFASLMPEAWHMVMWQMSDRTIPRSYRTIEGFGVHTFRLINAEGKSTFVKFHWKPRQGLQSVVWNEAVKINGADPDFHRRDLWEAIDSGDFPQWDLGVQLFDQATADGLPFDHLDATKLIPEEDVPVRLIGTLTLNRNVDNFFAETEQVAFCTANVPPGIDFSDDPLLHGRNFSYLDTQLKRLGGPNFTHIPVNAPRCPVMHFQQDGHMAMVNPKGRANYEPNSWGPEG |
Sequence similarities
Belongs to the catalase family. HPII subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length725
- Mass (Da)78,958
- Last updated2017-06-07 v1
- ChecksumC846B7E371923F19
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-21 | Basic and acidic residues | ||||
Sequence: MPKPDKAQRSDKSKQKGETPK | ||||||
Compositional bias | 33-68 | Polar residues | ||||
Sequence: PTSYAEPQGNGGETHQTTSDPAATMTSQQGIPISDG |