A0A1Q3C4J0 · A0A1Q3C4J0_CEPFO
- ProteinKH_1 domain-containing protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids625 (go to sequence)
- Protein existencePredicted
- Annotation score1/5
Function
function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | anchoring junction | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | podosome | |
Molecular Function | mRNA binding | |
Biological Process | regulation of gene expression |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Oxalidales > Cephalotaceae > Cephalotus
Accessions
- Primary accessionA0A1Q3C4J0
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-30 | Disordered | ||||
Sequence: MGENGKRTRHQGHNDKDSKNQKRRLNDKDE | ||||||
Domain | 35-120 | K Homology | ||||
Sequence: EVVVYRILCPVGVIGSVIGKSGKVINSIRLETRAKIKVVDPFPGAKDRVITIYSYVKEKDDVEIDDEFDDQEPLCAAQDALLKVQA | ||||||
Domain | 139-217 | K Homology | ||||
Sequence: NKEECQILVPSSQSANIIGKAGATIKKLRSKTRTNIKVTPKDPKDPTQSCAMDFDNFVLITGDSEAVKKALFAVSAIMY | ||||||
Domain | 307-380 | K Homology | ||||
Sequence: EELIIRVLCPFNKIGRVIGKGGGTIKNIRQASGAHVEVDDTKADRDECVITVTTTEAPDDLKSMAVESVLLLQE | ||||||
Domain | 388-462 | K Homology | ||||
Sequence: DTVTMRLLVPSKIIGCLIGKSGSIINEIRKRTKADVRISKGEKPKCADVHDELVEVVGEVGSVRDALIQIVLRLR | ||||||
Domain | 553-623 | K Homology | ||||
Sequence: PPSAVEMLVPANAVGKVLGKGGANVANIRKISGAMVEISESKSSRGDRVARISGTAEQRRTAENLIQAFIM |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length625
- Mass (Da)66,870
- Last updated2017-04-12 v1
- ChecksumC03F15BA0C8F58E4
Keywords
- Technical term