A0A1Q3C4J0 · A0A1Q3C4J0_CEPFO

Function

function

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentanchoring junction
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentpodosome
Molecular FunctionmRNA binding
Biological Processregulation of gene expression

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • KH_1 domain-containing protein

Gene names

    • ORF names
      CFOL_v3_18511

Organism names

  • Taxonomic identifier
  • Strain
    • cv. St1
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Oxalidales > Cephalotaceae > Cephalotus

Accessions

  • Primary accession
    A0A1Q3C4J0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-30Disordered
Domain35-120K Homology
Domain139-217K Homology
Domain307-380K Homology
Domain388-462K Homology
Domain553-623K Homology

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    625
  • Mass (Da)
    66,870
  • Last updated
    2017-04-12 v1
  • Checksum
    C03F15BA0C8F58E4
MGENGKRTRHQGHNDKDSKNQKRRLNDKDEKNNDEVVVYRILCPVGVIGSVIGKSGKVINSIRLETRAKIKVVDPFPGAKDRVITIYSYVKEKDDVEIDDEFDDQEPLCAAQDALLKVQAAISSAVAGAGESDKKRKDNKEECQILVPSSQSANIIGKAGATIKKLRSKTRTNIKVTPKDPKDPTQSCAMDFDNFVLITGDSEAVKKALFAVSAIMYKFTPREEISLDTNVPEAPPSIIIPSDVPLYPTGGLYPNADSVVSSRSVPSILSATHVPDLQGYVDTGNTWPVYSSALPVVPGLGGASNSEELIIRVLCPFNKIGRVIGKGGGTIKNIRQASGAHVEVDDTKADRDECVITVTTTEAPDDLKSMAVESVLLLQEKINDENVDTVTMRLLVPSKIIGCLIGKSGSIINEIRKRTKADVRISKGEKPKCADVHDELVEVVGEVGSVRDALIQIVLRLRDDVLKDKESGHNPPVGADSVYPGGASFSMPSLLPSVPPVAHLGYDQRHESGSGLGVLSSSNLFGYGSLPMGDSGYGSVSAYSSKLYEGLTPPSAVEMLVPANAVGKVLGKGGANVANIRKISGAMVEISESKSSRGDRVARISGTAEQRRTAENLIQAFIMST

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDDD01001301
EMBL· GenBank· DDBJ
GAV75031.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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