A0A1I1DC51 · A0A1I1DC51_9BACT
- ProteinAdenosylhomocysteinase
- GeneahcY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids435 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 58 | substrate | ||||
Sequence: T | ||||||
Binding site | 134 | substrate | ||||
Sequence: D | ||||||
Binding site | 159 | substrate | ||||
Sequence: E | ||||||
Binding site | 160-162 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TTT | ||||||
Binding site | 189 | substrate | ||||
Sequence: K | ||||||
Binding site | 193 | substrate | ||||
Sequence: D | ||||||
Binding site | 194 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 223-228 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GFGDVG | ||||||
Binding site | 225-230 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GDVGKG | ||||||
Binding site | 246 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 281 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 302-304 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: IGH | ||||||
Binding site | 349 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 356 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | L-homocysteine biosynthetic process | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Cytophagia > Cytophagales > Flexibacteraceae > Flexibacter
Accessions
- Primary accessionA0A1I1DC51
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 194-355 | S-adenosyl-L-homocysteine hydrolase NAD binding | ||||
Sequence: NLYGCKESCVDAIRRATDVMMAGKVAVVAGFGDVGKGSAKSLRGAGARVIVTEIDPICALQAAMEGYQVMKMDKAAELGDIFVTATGNMNIITERHFRKMRDKAIVCNIGHFDTEIDMAWLNNNYGSTKVEVKPQVDIYNVDGKEVIVLAEGRLVNLGCATG |
Sequence similarities
Belongs to the adenosylhomocysteinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length435
- Mass (Da)48,192
- Last updated2017-11-22 v1
- ChecksumA2CF71734E60C12C
Keywords
- Technical term