A0A1G7DHG0 · A0A1G7DHG0_9DEIN

  • Protein
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • Gene
    ispG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site297[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site300[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site343[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site350[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)
Molecular Function4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin)
Molecular Functioniron ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • EC number
  • Alternative names
    • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

Gene names

    • Name
      ispG
    • ORF names
      SAMN04488243_102139

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CGMCC 1.6992
  • Taxonomic lineage
    Bacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus

Accessions

  • Primary accession
    A0A1G7DHG0

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the IspG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    406
  • Mass (Da)
    44,120
  • Last updated
    2017-11-22 v1
  • Checksum
    4DBA9704D8BDAAC5
MEGMRRPTPTVYVGRVPIGGAHPIAVQSMTNTPTRDVEATTAQVLELYRAGSEIVRLTVNDEEAAKAVPEIKRRLLAEGAEVPLVGDFHFNGHLLLRKYPKMAEALDKFRINPGTLGRGRHKDEHFAEMVRIATDLGKPVRIGANWGSLDPALLTELMDRNAKRPEPKSAHEVVLEALVESAVRAYEAALEMGLGPDKLVLSAKVSKARDLVWVYRELARRTQAPLHLGLTEAGMGVKGIVASAAALAPLLLEGIGDTIRVSLTPGPKEPRTKEVEVAQEILQALGLRAFAPEVTSCPGCGRTTSTFFQELAEEVSRRLKERLPEWRARYPGVEELKVAVMGCVVNGPGESKHAHIGISLPGAGEEPKAPVYADGKLLTILKGEGIAEEFLRLVEDYVKARFAPKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FNBC01000002
EMBL· GenBank· DDBJ
SDE50480.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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