A0A1E3LHG6 · A0A1E3LHG6_9BURK

  • Protein
    Kynurenine formamidase
  • Gene
    kynB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 zinc ions per subunit.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15substrate
Binding site45Zn2+ 1 (UniProtKB | ChEBI)
Binding site49Zn2+ 1 (UniProtKB | ChEBI)
Binding site51Zn2+ 1 (UniProtKB | ChEBI)
Binding site51Zn2+ 2 (UniProtKB | ChEBI)
Active site55Proton donor/acceptor
Binding site157Zn2+ 2 (UniProtKB | ChEBI)
Binding site169Zn2+ 1 (UniProtKB | ChEBI)
Binding site169Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionarylformamidase activity
Molecular Functionformamidase activity
Molecular Functionzinc ion binding
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynurenine formamidase
  • EC number
  • Short names
    KFA
    ; KFase
  • Alternative names
    • Arylformamidase
    • N-formylkynurenine formamidase
      (FKF
      )

Gene names

    • Name
      kynB
    • ORF names
      A9762_20380

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ISTKB
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Pandoraea

Accessions

  • Primary accession
    A0A1E3LHG6

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the Cyclase 1 superfamily. KynB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    205
  • Mass (Da)
    22,168
  • Last updated
    2017-01-18 v1
  • Checksum
    CF0786F4301E87C4
MWDISAPLSASTPVWPGDTPFAEEAVWQIGPGCPVNVGRITLSPHTGAHADAPRHYDDAGAFIGEVDLQTYLGPCRVIHCIGASPVVTPEMVEAHLKDVPPRVLLRTYAHAPVAQWDSAFCAVAPETIDLLASHGVKLVGIDTPSLDPQESKTMDAHHRIRAHRMAILEGLVLDAIEPADYELIALPLKFMRLDASPVRAVLRSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MAOS01000037
EMBL· GenBank· DDBJ
ODP33206.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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