A0A1E1WVX7 · A0A1E1WVX7_TITOB

Function

function

Acts as a metalloprotease. Penetrates intact tissue and specifically cleaves the vesicle-associated membrane protein 2 (VAMP2) (part of the SNARE complex) involved in pancreatic secretion, thus disrupting the normal vesicular traffic.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

139750100150200250300350
TypeIDPosition(s)Description
Binding site320Zn2+ (UniProtKB | ChEBI); catalytic
Active site321
Binding site324Zn2+ (UniProtKB | ChEBI); catalytic
Binding site330Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Putative metalloproteinase

Organism names

Accessions

  • Primary accession
    A0A1E1WVX7

Subcellular Location

Secreted

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain165-392Peptidase M12B

Sequence similarities

Belongs to the venom metalloproteinase (M12B) family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    397
  • Mass (Da)
    44,152
  • Last updated
    2017-01-18 v1
  • Checksum
    CF6CC3E791B2FD20
YIFLFATVSAIPTGRVEVVFPSVETSRSGVKSVKFRTLGEDIELKLEPAGDILAKDFAFYNGNHEKQHSVDVESLRRKLYKDRTNGAALLIDDNEQPPSIEGIVFSKLKISPHEWKQVSKDGKRAHKVEKLTSEKDYYLSDNVILSDFGREVKNFTRLDRDDQCLVIEILSVTESSLTERFETNEALTEYVTLMYSSAETILRQLDSGLQLRLSGIVAFTKETEPPLFKKNELKDGEYYSKLILPEIKNYFCKNPITSSKSADIIMLLITRFMTTLKADGSIQGFVAGRAYSGTVCDECNKVGVTRDSGSAVSGSMLSAHEMSHLLGVTHDGDPSKYTGVSGSPGAESCPSKDGFLMGYNRGDNRGIFSKCSKDCAKYLLSKPEASCVYEKCKNSRY

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GEMQ01000062
EMBL· GenBank· DDBJ
JAT91127.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

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