A0A1E1WVX7 · A0A1E1WVX7_TITOB
- ProteinPutative metalloproteinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids397 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Acts as a metalloprotease. Penetrates intact tissue and specifically cleaves the vesicle-associated membrane protein 2 (VAMP2) (part of the SNARE complex) involved in pancreatic secretion, thus disrupting the normal vesicular traffic.
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Scorpiones > Buthida > Buthoidea > Buthidae > Tityus
Accessions
- Primary accessionA0A1E1WVX7
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 165-392 | Peptidase M12B | ||||
Sequence: LVIEILSVTESSLTERFETNEALTEYVTLMYSSAETILRQLDSGLQLRLSGIVAFTKETEPPLFKKNELKDGEYYSKLILPEIKNYFCKNPITSSKSADIIMLLITRFMTTLKADGSIQGFVAGRAYSGTVCDECNKVGVTRDSGSAVSGSMLSAHEMSHLLGVTHDGDPSKYTGVSGSPGAESCPSKDGFLMGYNRGDNRGIFSKCSKDCAKYLLSKPEASCVYEKC |
Sequence similarities
Belongs to the venom metalloproteinase (M12B) family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length397
- Mass (Da)44,152
- Last updated2017-01-18 v1
- ChecksumCF6CC3E791B2FD20
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Y |