A0A1E1ITW8 · A0A1E1ITW8_LEIGU

  • Protein
    Alpha-tubulin N-acetyltransferase
  • Gene
    LgM4147LRVhigh.20.00771.00040
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.

Catalytic activity

Features

Showing features for site, binding site.

123620406080100120140160180200220
TypeIDPosition(s)Description
Site73Crucial for catalytic activity
Binding site134-147acetyl-CoA (UniProtKB | ChEBI)
Binding site171-180acetyl-CoA (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmicrotubule
Molecular Functiontubulin N-acetyltransferase activity
Biological Processregulation of microtubule cytoskeleton organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-tubulin N-acetyltransferase
  • EC number
  • Short names
    Alpha-TAT
    ; TAT
  • Alternative names
    • Acetyltransferase mec-17 homolog

Gene names

    • Name
      LgM4147LRVhigh.20.00771.00040
    • ORF names
      BN36_2022310

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MHOM/BR/75/M4147/SSU:IR2SAT-LUC
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > Leishmania guyanensis species complex

Accessions

  • Primary accession
    A0A1E1ITW8

Subcellular Location

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain21-201N-acetyltransferase
Region217-236Disordered

Sequence similarities

Belongs to the acetyltransferase ATAT1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    236
  • Mass (Da)
    25,909
  • Last updated
    2017-01-18 v1
  • Checksum
    4E76D0007F215561
MRLSAQLTNTKLADEQVPELASVPDGVSRWTGADLDRLRSAARRGGVGAEQQDLAQKLCRTIDILGARSQKTQGLNAVLTSVARLRESNTFRLYLLTQNHRGVGILKMGVKKLFVTHPVTCGLVEVDPLCVLDFYVDENCQRQGYGKKLYAHMLDAEHVSRPELLAIDRPSDKLLGFMKKHYGLTAYTPQVNKFVVFHGFFGHTTVSERGKLLRTTSPTGAAAAATGTKAKNEMPG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CALQ01000661
EMBL· GenBank· DDBJ
CCM14733.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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