A0A1B2VX45 · A0A1B2VX45_URSSP

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrion
Molecular Functioncytochrome-c oxidase activity
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 3

Gene names

    • Name
      COX3

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus

Accessions

  • Primary accession
    A0A1B2VX45

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane71-94Helical
Transmembrane151-169Helical
Transmembrane189-212Helical
Transmembrane232-252Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-253Heme-copper oxidase subunit III family profile

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    253
  • Mass (Da)
    28,849
  • Last updated
    2016-11-02 v1
  • Checksum
    B362B7BBEBCABC6E
HMVNPSPWPLTGALSALLMTSGLIMWFHFNSMLLLLLGLTTNMLTMYQWWRDIIRESTFQGHHTPAVQKGLRYGMVLFIVSEVFFFAGFFWAFYHSSLAPTPELGACWPPTGIAPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGSRKHMLQALFITISLGVYFTLLQASEYYEASFTISDGVYGSTFFMATGFHGLHVIIGSTFLTVCFLRQLYFHFTSSHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX641292
EMBL· GenBank· DDBJ
AOD41966.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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