A0A182WIE0 · A0A182WIE0_9DIPT

  • Protein
    KAT8 regulatory NSL complex subunit 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    2/5

Function

function

Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthistone acetyltransferase complex
Cellular Componentmitochondrion
Cellular Componentnucleus
Biological Processchromatin organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    KAT8 regulatory NSL complex subunit 2
  • Alternative names
    • NSL complex protein NSL2
    • Non-specific lethal 2 homolog

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MINIMUS1
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A182WIE0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region39-77Disordered
Domain93-158Potential DNA-binding
Compositional bias268-282Polar residues
Region268-288Disordered
Domain404-466Potential DNA-binding
Region485-624Disordered
Compositional bias496-522Polar residues
Compositional bias523-559Basic and acidic residues
Compositional bias560-574Polar residues
Compositional bias575-604Basic and acidic residues
Compositional bias605-623Polar residues
Region667-772Disordered
Compositional bias675-695Basic and acidic residues
Compositional bias696-742Polar residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    772
  • Mass (Da)
    86,340
  • Last updated
    2016-09-07 v1
  • Checksum
    6016BC19AA1F2A8C
MADLTTKVSIECRLDHLCQFDSLEQDCFKFLQMSQYNTSADNPMGPTQQQAAGRSASRSGTSGTSASASQGPDQAQALRSQIQLEIEQKAKVCANTQYECTLPRVESYVYCFRHILQDPNAPYKQCEFVFPNDRRCLEPSPKYDVKKDYGSNYCFEHSRQTQLKKTKSTIGKLVPVETTETLLHGLAHHVKVDKAKQHYMGNNTPLKITVHEDDEDADVDVVTPSVDPFVDVDVTAINDSGRIVLDYASDSSEDDETVLHPTFGSSWQAHEMDNSDNESVDSQGGDPLKHAGIYTAEEVTRITKEKLFRLQSLYIEQIHRLQHVLRERRRNYLKDQRAERDFHCSIYDQIKQTPRERLLYEKLKGLNRYHRKHGVEAILQRKYLEKRAKATEGLQQKPTSLPKCSFTEGGVKCGERTLPCCKHCRKHILEDKKQVLFRACGIEKSGVVCQETLAGLFENVTCPLHMELPAQRSFNKRKYESESEGECEISAMEVSSTVGGEKSSKVATDKSNHPATTTTSVETQDDKKAENLESKATTDEVDGKAAVKNESKRKVFKTESTTPTARLRNTRSSRAAIAKQEDEHKPDQGTPSTASDHEIKQEQKASQENVTIIHPPVTTTQMDDTDVDLEECLLPVSVIHKKKPIDEKNTTKPVVVTEMKNVMAVSAGSEIEKEPEPAIMGENVEMEEKTKKVTSVNATTDEANATDDQQSLSSSTTNQEAVVDTTTMSPDVANSSGSQQENDDQDESSKSPKVTLTSRQKKLLSGTDKKES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias268-282Polar residues
Compositional bias496-522Polar residues
Compositional bias523-559Basic and acidic residues
Compositional bias560-574Polar residues
Compositional bias575-604Basic and acidic residues
Compositional bias605-623Polar residues
Compositional bias675-695Basic and acidic residues
Compositional bias696-742Polar residues

Genome annotation databases

Similar Proteins

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