A0A182WIE0 · A0A182WIE0_9DIPT
- ProteinKAT8 regulatory NSL complex subunit 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids772 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | histone acetyltransferase complex | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Biological Process | chromatin organization |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameKAT8 regulatory NSL complex subunit 2
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles
Accessions
- Primary accessionA0A182WIE0
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 39-77 | Disordered | ||||
Sequence: SADNPMGPTQQQAAGRSASRSGTSGTSASASQGPDQAQA | ||||||
Domain | 93-158 | Potential DNA-binding | ||||
Sequence: CANTQYECTLPRVESYVYCFRHILQDPNAPYKQCEFVFPNDRRCLEPSPKYDVKKDYGSNYCFEHS | ||||||
Compositional bias | 268-282 | Polar residues | ||||
Sequence: QAHEMDNSDNESVDS | ||||||
Region | 268-288 | Disordered | ||||
Sequence: QAHEMDNSDNESVDSQGGDPL | ||||||
Domain | 404-466 | Potential DNA-binding | ||||
Sequence: CSFTEGGVKCGERTLPCCKHCRKHILEDKKQVLFRACGIEKSGVVCQETLAGLFENVTCPLHM | ||||||
Region | 485-624 | Disordered | ||||
Sequence: GECEISAMEVSSTVGGEKSSKVATDKSNHPATTTTSVETQDDKKAENLESKATTDEVDGKAAVKNESKRKVFKTESTTPTARLRNTRSSRAAIAKQEDEHKPDQGTPSTASDHEIKQEQKASQENVTIIHPPVTTTQMDD | ||||||
Compositional bias | 496-522 | Polar residues | ||||
Sequence: STVGGEKSSKVATDKSNHPATTTTSVE | ||||||
Compositional bias | 523-559 | Basic and acidic residues | ||||
Sequence: TQDDKKAENLESKATTDEVDGKAAVKNESKRKVFKTE | ||||||
Compositional bias | 560-574 | Polar residues | ||||
Sequence: STTPTARLRNTRSSR | ||||||
Compositional bias | 575-604 | Basic and acidic residues | ||||
Sequence: AAIAKQEDEHKPDQGTPSTASDHEIKQEQK | ||||||
Compositional bias | 605-623 | Polar residues | ||||
Sequence: ASQENVTIIHPPVTTTQMD | ||||||
Region | 667-772 | Disordered | ||||
Sequence: AGSEIEKEPEPAIMGENVEMEEKTKKVTSVNATTDEANATDDQQSLSSSTTNQEAVVDTTTMSPDVANSSGSQQENDDQDESSKSPKVTLTSRQKKLLSGTDKKES | ||||||
Compositional bias | 675-695 | Basic and acidic residues | ||||
Sequence: PEPAIMGENVEMEEKTKKVTS | ||||||
Compositional bias | 696-742 | Polar residues | ||||
Sequence: VNATTDEANATDDQQSLSSSTTNQEAVVDTTTMSPDVANSSGSQQEN |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length772
- Mass (Da)86,340
- Last updated2016-09-07 v1
- Checksum6016BC19AA1F2A8C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 268-282 | Polar residues | ||||
Sequence: QAHEMDNSDNESVDS | ||||||
Compositional bias | 496-522 | Polar residues | ||||
Sequence: STVGGEKSSKVATDKSNHPATTTTSVE | ||||||
Compositional bias | 523-559 | Basic and acidic residues | ||||
Sequence: TQDDKKAENLESKATTDEVDGKAAVKNESKRKVFKTE | ||||||
Compositional bias | 560-574 | Polar residues | ||||
Sequence: STTPTARLRNTRSSR | ||||||
Compositional bias | 575-604 | Basic and acidic residues | ||||
Sequence: AAIAKQEDEHKPDQGTPSTASDHEIKQEQK | ||||||
Compositional bias | 605-623 | Polar residues | ||||
Sequence: ASQENVTIIHPPVTTTQMD | ||||||
Compositional bias | 675-695 | Basic and acidic residues | ||||
Sequence: PEPAIMGENVEMEEKTKKVTS | ||||||
Compositional bias | 696-742 | Polar residues | ||||
Sequence: VNATTDEANATDDQQSLSSSTTNQEAVVDTTTMSPDVANSSGSQQEN |