A0A168QEH2 · A0A168QEH2_MUCCL

Function

function

NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H2O2-induced cell death.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site58-61FMN (UniProtKB | ChEBI)
Binding site96-105FMN (UniProtKB | ChEBI)
Binding site131FMN (UniProtKB | ChEBI)
Binding site336FAD (UniProtKB | ChEBI)
Binding site366-369FAD (UniProtKB | ChEBI)
Binding site442NADP+ (UniProtKB | ChEBI)
Binding site498-499NADP+ (UniProtKB | ChEBI)
Binding site504-508NADP+ (UniProtKB | ChEBI)
Binding site579FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processiron-sulfur cluster assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent diflavin oxidoreductase 1
  • EC number
  • Alternative names
    • NADPH-dependent FMN and FAD-containing oxidoreductase

Gene names

    • Name
      TAH18
    • ORF names
      MUCCIDRAFT_136898

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 277.49
  • Taxonomic lineage
    Eukaryota > Fungi > Fungi incertae sedis > Mucoromycota > Mucoromycotina > Mucoromycetes > Mucorales > Mucorineae > Mucoraceae > Mucor

Accessions

  • Primary accession
    A0A168QEH2

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Mitochondrion
Note: Relocalizes to mitochondria after H2O2 exposure.

Keywords

Interaction

Subunit

Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-149Flavodoxin-like
Domain190-428FAD-binding FR-type

Sequence similarities

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    580
  • Mass (Da)
    67,097
  • Last updated
    2016-07-06 v1
  • Checksum
    85AABE53748CC8B9
MDRSLLILFGSETGCAQDVAENLARQARRRHFKTRVVAMDDYDKSQLVEEKLVFFVCSTTGQGIEPANMKKFWKFLLRKNLPNDILSDLDCAVLGLGDSSYRKFNYPSKKLYKRLLQLGANMIVDRGDCDDQHYLGLDGAFVPWAKNLWDVVLEKYPASEPLIPDDVLLPPSFRMEFITDGQAQPQTTLAEEFNLVVRKNERITAADHFQDVRHIELACTDQDFKYEPGDIAVITPQNLVQDVDLFFEQLGWTEHADKLIRFTPFDEFHTLPAHWPSVMTFRDLFVYFLDVFGVPRRSFFEMLAYFTTDENHTERLREFASPQGQEDMWAYCARPRRHIGEVLFDFKPFDIPFDYMLDLFPQLQPRSFSIASSLNVHPKSMELCVAVVKYKTKMRKIRRGVFTKWMSTWEEGDVIPRVRIAKGTMTLPPSQDIPLIAIGPGTGVAPMRSFLEERIVEQGATQNVLLFGCRYHDKDFYFADQWKEYEQNGQLVLLTAFSRDQDSKVYVQDKIRQHSELLWDLIENQQAKVVLSGSLDKMPGEVAYAFKQIFMKEGGLDAAEAEGYFSDMIKSGQYQEECWN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AMYB01000001
EMBL· GenBank· DDBJ
OAD09126.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp