A0A0T5ZYC8 · A0A0T5ZYC8_UNCKA

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site18-23GTP (UniProtKB | ChEBI)
Binding site134-137GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • ORF names
      XU08_C0001G0185

Organism names

Accessions

  • Primary accession
    A0A0T5ZYC8

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-185Tr-type G

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    567
  • Mass (Da)
    63,186
  • Last updated
    2016-02-17 v1
  • Checksum
    0574955919D65798
MSTSTANIRNFAIIAHIDHGKSTLADRLMERTGLLPPAETETPRIDRMELETERGVTIKLKAVRLPFELLSAKYSLNMIDTPGHADFSYEVSRSLAACEGVLLLVDATQGVQAQTLSHLETARELGLAVVGVINKIDSPLARIPETEKELRDLGIEGEILRLSALEGEGIDEVLRAVVERIPPPQGKLIEPFRALVFDSTFDPHLGTIAYVRVVDGEIESANRPTVKFLGTKASAQVKEIGYFSPDRKPTFALRTGEIGSIATGIRDPREVRVGDTVVLTNQTTALPGYQPPQSYVFASFFAKNSDFAEFRRALQTLRLEEPAISIEEISSTAFGRGFRIGFLGTFHLEIVRERLTREFGLELVVTKPTVSFRGLEEEPWILLTVLTPSEYLARVARLVAERRGKLGETETLGNRLKFSAELPLLEFVRGFYDALKSISHGYASLSWEFLDYRSAPLVELDILVHEDLVEGLTEIVLRDEAERMGREKLKKLKEILPRQLFAYAIQARSAGKILAREDISAVRKDVLAKLSGGHVERKMKKLQEQKKGKKKLAKFGRVEMPPAAFLV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LDXK01000001
EMBL· GenBank· DDBJ
KRT67775.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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