A0A0L0NVZ1 · A0A0L0NVZ1_CANAR
- ProteintRNA-dihydrouridine(47) synthase [NAD(P)(+)]
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids606 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.
Catalytic activity
- 5,6-dihydrouridine47 in tRNA + NAD+ = uridine47 in tRNA + NADH + H+This reaction proceeds in the backward direction.
- a 5,6-dihydrouridine in mRNA + NAD+ = a uridine in mRNA + NADH + H+This reaction proceeds in the backward direction.
- a 5,6-dihydrouridine in mRNA + NADP+ = a uridine in mRNA + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA dihydrouridine synthase activity | |
Molecular Function | RNA binding | |
Molecular Function | tRNA-dihydrouridine47 synthase activity | |
Biological Process | mRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA-dihydrouridine(47) synthase [NAD(P)(+)]
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Metschnikowiaceae > Metschnikowiaceae incertae sedis > Candida/Metschnikowiaceae
Accessions
- Primary accessionA0A0L0NVZ1
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-83 | Disordered | ||||
Sequence: MTQEKNENGNVNIEPAAKRARTDDTEKGYAPIKPEFIIDGVKVEETYDDEAAEEGDRGAQPESSKRSKKNRGQNKKRDLKQQK | ||||||
Compositional bias | 53-68 | Basic and acidic residues | ||||
Sequence: EEGDRGAQPESSKRSK | ||||||
Domain | 83-115 | C3H1-type | ||||
Sequence: KEEVRLCSSILDPSDPKECKFGADKCKNTHDVD | ||||||
Zinc finger | 83-115 | C3H1-type | ||||
Sequence: KEEVRLCSSILDPSDPKECKFGADKCKNTHDVD |
Sequence similarities
Belongs to the dus family. Dus3 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length606
- Mass (Da)68,919
- Last updated2015-11-11 v1
- ChecksumF914556A8D35A779
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 53-68 | Basic and acidic residues | ||||
Sequence: EEGDRGAQPESSKRSK |