A0A0I1Z9C6 · A0A0I1Z9C6_SHISO

  • Protein
    Hydroxyacylglutathione hydrolase
  • Gene
    gloB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site53Zn2+ 1 (UniProtKB | ChEBI)
Binding site55Zn2+ 1 (UniProtKB | ChEBI)
Binding site57Zn2+ 2 (UniProtKB | ChEBI)
Binding site58Zn2+ 2 (UniProtKB | ChEBI)
Binding site110Zn2+ 1 (UniProtKB | ChEBI)
Binding site127Zn2+ 2 (UniProtKB | ChEBI)
Binding site127Zn2+ 1 (UniProtKB | ChEBI)
Binding site165Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydroxyacylglutathione hydrolase activity
Molecular Functionmetal ion binding
Biological Processmethylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxyacylglutathione hydrolase
  • EC number
  • Alternative names
    • Glyoxalase II
      (Glx II
      )

Gene names

    • Name
      gloB
    • ORF names
      BZ172_16885
      , ERS009857_01258
      , ERS428554_03459
      , FIO44_005044
      , SAMEA1569760_03259
      , SAMEA2054241_02998
      , SAMEA3710766_03386

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 20352044
    • 2090STDY5461769
    • Sh1274_441042
    • sh1405
    • Sh1405
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella

Accessions

  • Primary accession
    A0A0I1Z9C6

Proteomes

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-165Metallo-beta-lactamase

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    251
  • Mass (Da)
    28,420
  • Last updated
    2015-10-14 v1
  • Checksum
    D1C80DA6A02F0982
MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAIAANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTASQMYQSLNKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLQQPEERFAWLRSKKDRF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019689
EMBL· GenBank· DDBJ
ARS06833.1
EMBL· GenBank· DDBJ
Genomic DNA
CWXZ01000104
EMBL· GenBank· DDBJ
CSK92995.1
EMBL· GenBank· DDBJ
Genomic DNA
CXDQ01000027
EMBL· GenBank· DDBJ
CSR53954.1
EMBL· GenBank· DDBJ
Genomic DNA
AAUUDD010000085
EMBL· GenBank· DDBJ
EFW7017593.1
EMBL· GenBank· DDBJ
Genomic DNA
FTSV01000104
EMBL· GenBank· DDBJ
SIX95090.1
EMBL· GenBank· DDBJ
Genomic DNA
FUBI01000101
EMBL· GenBank· DDBJ
SJH40460.1
EMBL· GenBank· DDBJ
Genomic DNA
UDYI01000104
EMBL· GenBank· DDBJ
SRR24369.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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