A0A0H4APX4 · A0A0H4APX4_DUGDU

Function

function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

Catalytic activity

Features

Showing features for active site.

137750100150200250300350
TypeIDPosition(s)Description
Active site137Acyl-ester intermediate
Active site264Charge relay system
Active site377Charge relay system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functionacetylcholinesterase activity
Biological Processacetylcholine catabolic process
Biological Processcholine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carboxylic ester hydrolase
  • EC number

Gene names

    • Name
      BCHE

Organism names

  • Taxonomic identifier
  • Strain
    • MD33
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Afrotheria > Sirenia > Dugongidae > Dugong

Accessions

  • Primary accession
    A0A0H4APX4

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Homotetramer; disulfide-linked. Dimer of dimers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-377Carboxylesterase type B

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    377
  • Mass (Da)
    42,301
  • Last updated
    2015-10-14 v1
  • Checksum
    194236571046541E
ANSCYQNTDQSFPGFLGSEMWNPNTDLSEDCLYLNVWTPMPKPKNATVMVWIYGGAFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNHEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPRSHPFFTRAILQSGSSNAPWAVMSIYEARNRTLTLAKFLGCSRENETEIIKCLQNKDPQEILLNEVFVVPYESLLSVNFGPTVDGDFLIDMPDTLLQLGQFKKTQIMVGVNKDEGTAFLVYGAPGFSKDNNSIISRTQFQEGLKIFFPGVSDFGKESILFHYTDWLDDQRPEHYREALDDVVGDYNIICPALEFTRKFSELGNNAFFYYFEHRSSKLPWPEWMGVMH

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue377

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR827306
EMBL· GenBank· DDBJ
AKN52387.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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