A0A0F7GDC4 · A0A0F7GDC4_9CHLR

Function

function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site228S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site257S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site278S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site321S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site348
Active site348Nucleophile
Site412Important for substrate specificity
Active site469Proton acceptor
Site470Important for substrate specificity
Site554Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondTTP diphosphatase activity
Molecular FunctionRNA methyltransferase activity
Molecular FunctionS-adenosylmethionine-dependent methyltransferase activity
Molecular FunctionUTP diphosphatase activity
Biological Processmethylation
Biological Processnucleotide metabolic process
Biological ProcessRNA modification
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dTTP/UTP pyrophosphatase
  • EC number
  • Short names
    dTTPase/UTPase
  • Alternative names
    • Nucleoside triphosphate pyrophosphatase
    • Nucleotide pyrophosphatase
      (Nucleotide PPase
      )

Gene names

    • Name
      maf
    • ORF names
      DGWBC_0770

Organism names

  • Taxonomic identifier
  • Strain
    • WBC-2
  • Taxonomic lineage
    Bacteria > Chloroflexota > Dehalococcoidia > Dehalococcoidales > Dehalococcoidaceae > Dehalogenimonas

Accessions

  • Primary accession
    A0A0F7GDC4

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the Maf family. YhdE subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    610
  • Mass (Da)
    67,727
  • Last updated
    2015-07-22 v1
  • Checksum
    D10E6E1907A08773
MMESEIISVDLSGLDDFGHALGDYKGVQVNVFGGIPGETVAARIIEHNGIKIEAVVEDTTIPSPHRRMPPCPLFGECSGCQWQHINYEHQLELKRDLIRRALLAKGLNDSLVLPIVPSPDEFGYRNHARFTVRRRLNRFGFINRITRRFVPVSQCLIMTEGINKLMASLEGQCTETTQFSIRCGINTDEYLIQPKLTNLEVTVTTGQQYYHEVLLGHHFRVSSPSFFQVNTPQAERLALIIIEYLKLNGSETIIDAYAGVATFAALMAPHVKRVIAIEESGAAVKDARENVRNLQNVEILEAKTESVLPHLGKLTDAIIIDPSRNGCHHTTLKTLNLYPPKRLVYVSCDPKTLARDLKVLSRGPYEIESITPVDLFPQTYHVETVSTLSWNSEKEQAFLNRQRLILASASPRRADILTSMGLKFTITESGIAEIPTDGLLPEDQAQAFARAKATAVASKYENGVVITADTIVVLDNELLGKPRSPEEAIGILGRLRGRTHRVVTAVAVTDTATGETIADSCTSQVTMRHYTDEEIQDYVNSGLSTDKAGAYGIQDKEFHPVARIKGCYNNVVGLPVCLMLDILLKLGVHPVISSHWRCQTECPNRNKWGQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011392
EMBL· GenBank· DDBJ
AKG53442.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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