A0A0F7GDC4 · A0A0F7GDC4_9CHLR
- ProteindTTP/UTP pyrophosphatase
- Genemaf
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids610 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Catalytic activity
- H2O + UTP = diphosphate + H+ + UMP
Cofactor
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 228 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 257 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 278 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 321 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 348 | |||||
Sequence: C | ||||||
Active site | 348 | Nucleophile | ||||
Sequence: C | ||||||
Site | 412 | Important for substrate specificity | ||||
Sequence: R | ||||||
Active site | 469 | Proton acceptor | ||||
Sequence: D | ||||||
Site | 470 | Important for substrate specificity | ||||
Sequence: T | ||||||
Site | 554 | Important for substrate specificity | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dTTP diphosphatase activity | |
Molecular Function | RNA methyltransferase activity | |
Molecular Function | S-adenosylmethionine-dependent methyltransferase activity | |
Molecular Function | UTP diphosphatase activity | |
Biological Process | methylation | |
Biological Process | nucleotide metabolic process | |
Biological Process | RNA modification | |
Biological Process | RNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedTTP/UTP pyrophosphatase
- EC number
- Short namesdTTPase/UTPase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Chloroflexota > Dehalococcoidia > Dehalococcoidales > Dehalococcoidaceae > Dehalogenimonas
Accessions
- Primary accessionA0A0F7GDC4
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the Maf family. YhdE subfamily.
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length610
- Mass (Da)67,727
- Last updated2015-07-22 v1
- ChecksumD10E6E1907A08773
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP011392 EMBL· GenBank· DDBJ | AKG53442.1 EMBL· GenBank· DDBJ | Genomic DNA |