A0A093V1F9 · A0A093V1F9_TALMA

  • Protein
    Cytoplasmic tRNA 2-thiolation protein 2
  • Gene
    NCS2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm5 tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Pathway

tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Functionnucleotidyltransferase activity
Molecular Functionsulfurtransferase activity
Molecular FunctiontRNA binding
Biological Processprotein urmylation
Biological ProcesstRNA wobble position uridine thiolation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytoplasmic tRNA 2-thiolation protein 2

Gene names

    • Name
      NCS2
    • Synonyms
      CTU2
    • ORF names
      GQ26_0191150
      , GQ26_0300310

Organism names

  • Taxonomic identifier
  • Strain
    • PM1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces

Accessions

  • Primary accession
    A0A093V1F9

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the CTU2/NCS2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    38,985
  • Last updated
    2014-11-26 v1
  • Checksum
    821F199D538C9B3B
MPAKEISQICVSCKEVEALATIRNRPLCRDCFIDYAGRKVAAVMSAYRPQKNVTPPKVLLPLSLGISSSSLLHIVDRLQKFQLNRSLATAGFDLHVLVVDPTTVHPGYTDVKANSDSAKETFPNHTYTMIPLHRIFEYDATINDTLRDFGFVGENFGSDKERLDAFRASMSTTTARDDIDNLLLVRLIVAFAKNNDCRGILWGDSDSRLAAKTLANVAKGRGASLTWQVCDGVSPWGLHFSFPLRELYKFELEIYVKQIPELASIIIPDLQVQENEANRNLSIDNLMNLYVKTQGEKYPGVMANVVRTANKLRPTSNTEAVKCSLCAAPVDQTATLCYACLRSRADVLQHA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPOX01000030
EMBL· GenBank· DDBJ
KFX44103.1
EMBL· GenBank· DDBJ
Genomic DNA
JPOX01000019
EMBL· GenBank· DDBJ
KFX46377.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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