A0A091NN77 · A0A091NN77_APAVI
- ProteinHistone-lysine N-methyltransferase SETD7
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids357 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine
- L-lysyl-[protein] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 217-219 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: AGE | ||||||
Site | 236 | Histone H3K4 binding | ||||
Sequence: Y | ||||||
Site | 247 | Histone H3K4 binding | ||||
Sequence: D | ||||||
Site | 257 | Histone H3K4 binding | ||||
Sequence: T | ||||||
Binding site | 287 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 288 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 308 | Histone H3K4 binding | ||||
Sequence: K | ||||||
Site | 326 | Histone H3K4 binding | ||||
Sequence: Y | ||||||
Binding site | 347 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | nucleus | |
Molecular Function | histone H3K4 monomethyltransferase activity | |
Biological Process | methylation | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase SETD7
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Trogoniformes > Trogonidae > Apaloderma
Accessions
- Primary accessionA0A091NN77
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 205-327 | SET | ||||
Sequence: ERVYVDVSLISSAGEGLFSKIAAEARTVMSFYNGVRITHQEVDSRDWALNGNTISLDDETVIDVPEPYNHASKYCASLGHKANHSFTPNCIYDPFVHPRFGPIKCIRTIRAVEKDEELTVAYG |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length357
- Mass (Da)39,597
- Last updated2014-11-26 v1
- Checksum74C44BC7613EAD93
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E | ||||||
Non-terminal residue | 357 | |||||
Sequence: K |
Keywords
- Technical term