A0A089YPT6 · A0A089YPT6_9PSED

Function

function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Ni2+ (UniProtKB | Rhea| CHEBI:49786 )

Note: Binds 1 nickel ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site93Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site120Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Active site166Proton donor/acceptor
Binding site166Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular Functionlactoylglutathione lyase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lactoylglutathione lyase
  • EC number
  • Alternative names
    • Glyoxalase I

Gene names

    • ORF names
      LT40_09565

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 16299
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A089YPT6

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-170VOC

Sequence similarities

Belongs to the glyoxalase I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    172
  • Mass (Da)
    19,414
  • Last updated
    2014-11-26 v1
  • Checksum
    56F206F38F3EBF11
MSLDHLNSVPGVTAQPEAATSQFVFNHTMLRVKNIEKSLDFYTRVLGFSLVEKRDFAEAQFSLYFLALVDKSTIPTDDKARTTWMKSMPGVLELTHNHGTENDADFAYHDGNSDPRGFGHICVSVPDIHAACERFETLGVDFQKRLTDGRMKSIAFIKDPDGYWVEIIQPDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009533
EMBL· GenBank· DDBJ
AIS17629.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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