A0A089YPT6 · A0A089YPT6_9PSED
- ProteinLactoylglutathione lyase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids172 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Catalytic activity
- (R)-S-lactoylglutathione = glutathione + methylglyoxal
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 nickel ion per subunit.
Note: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
Pathway
Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 93 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: E | ||||||
Binding site | 120 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: H | ||||||
Active site | 166 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 166 | Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | lactoylglutathione lyase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLactoylglutathione lyase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A089YPT6
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 24-170 | VOC | ||||
Sequence: VFNHTMLRVKNIEKSLDFYTRVLGFSLVEKRDFAEAQFSLYFLALVDKSTIPTDDKARTTWMKSMPGVLELTHNHGTENDADFAYHDGNSDPRGFGHICVSVPDIHAACERFETLGVDFQKRLTDGRMKSIAFIKDPDGYWVEIIQP |
Sequence similarities
Belongs to the glyoxalase I family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length172
- Mass (Da)19,414
- Last updated2014-11-26 v1
- Checksum56F206F38F3EBF11
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP009533 EMBL· GenBank· DDBJ | AIS17629.1 EMBL· GenBank· DDBJ | Genomic DNA |