A0A076HRA6 · A0A076HRA6_9BACT

  • Protein
    ACT domain-containing protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Recommended name
    ACT domain-containing protein

Gene names

    • ORF names
      N008_08750

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • APR13
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Hymenobacteraceae > Hymenobacter

Accessions

  • Primary accession
    A0A076HRA6

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain400-478ACT

Sequence similarities

Belongs to the aspartokinase family.
In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    814
  • Mass (Da)
    87,817
  • Last updated
    2014-10-29 v1
  • Checksum
    86E3B6043825E823
MQVLKFGGTSVATAANLQRVARLAEAAARQQPTIVVVSALGGTTDLLIEAGRAAAAGHQDYRAHLRQLELRHLEAVRGLLPVPEQSEVLSFVKSSCNELENLCDGIFALGELSDRTLDRLMSYGELLASGLLAAALRSHGTPHLWHDSRQLIRTNSQHGFAAVDVAFTNLQIREFVVAQPAALYVVPGFIGSDAHGATTTLGRGGSDYTAALFAGALAAERLEIWTDVSGMMTADPRLVSAARPIPRISYQEAMELSHFGAKVLYPPTIQPVMSQGIPLWIKNTFAPDDAGTLVEVRPPANHEVVRGLSSISGLALLSLEGSGMVGIPGFSRRLFGVLAQERINVILITQSSSEHSICVAVRAADAPHAQVAVDEEFGPEIAAGRVDPLRLETDLAIVALVGEQMRNHSGISGRMFGALGNNGVNIRAIAQGSSERNISVVIRAHDVRKAINVLHEDFFEESVKQVNVFVAGVGNVGGKLLEQLARQQPWLREKLRLNLRVVGLANSRRFVLDDNGLDLAHWPEALEQGQPLRLPELVRELQARNLRNTVFVDVTANADVANIYGQLLEKSIAVVACNKVAASAEYASYARLKALAREFSAGFLFETNVGAGLPVIGTLNDLLRSGDEVRRMEAVLSGTLNFVFNHYDGSRPFAEVVRQAQTEGYTEPDPRLDLNGSDVARKILILAREAGQEMEMADIRNESFLPESCLAGDVEAFYEQLAVHEPHFRALYDAAAAEGKRLKFVARYADGQAGVGLQAVAPGHDFYDLQGKDNAVLFFTNRYPRQPLVVKGAGAGADVTASGVFADIVRAARV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006587
EMBL· GenBank· DDBJ
AII52066.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp