A0A069DW36 · A0A069DW36_9HEMI
- ProteinAutophagy-related protein 9
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids744 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | autophagosome | |
Cellular Component | phagophore assembly site membrane | |
Biological Process | autophagy of mitochondrion | |
Biological Process | lipid transport | |
Biological Process | protein localization to phagophore assembly site |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 9
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Reduviidae > Triatominae > Panstrongylus
Accessions
- Primary accessionA0A069DW36
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Preautophagosomal structure membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 56-78 | Helical | ||||
Sequence: LFQFIFVVIFSMFLLNCIDYPVL | ||||||
Transmembrane | 112-130 | Helical | ||||
Sequence: GLHWSVIIVAIVFWLLRAI | ||||||
Transmembrane | 272-296 | Helical | ||||
Sequence: ILYVAVVNLVLCPLILLWQILYSFF | ||||||
Transmembrane | 354-376 | Helical | ||||
Sequence: VMTVLAKNVVFVSGACLAVLLVL | ||||||
Transmembrane | 388-407 | Helical | ||||
Sequence: HVLSAITVLGAIVACFRALI | ||||||
Transmembrane | 455-476 | Helical | ||||
Sequence: ATYLLGEMVSPIVTPLVLIFYL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 517-540 | Disordered | ||||
Sequence: NQLGPTTWSSGDGPLEQPPPPPYA | ||||||
Region | 711-733 | Disordered | ||||
Sequence: VQRRGGDRSTSARPGGFTYSHER |
Sequence similarities
Belongs to the ATG9 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length744
- Mass (Da)84,356
- Last updated2014-10-01 v1
- ChecksumA6A5FFD05EB9E20B
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: D |