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Entry version 60 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase

Gene

AYJ03_005865

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseImported, OxidoreductaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomeraseImported
Submitted name:
Cholesterol dehydrogenaseImported (EC:1.1.1.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AYJ03_005865Imported, DSI38_25275Imported, E5M05_10565Imported, ERS007661_00195Imported, ERS007665_00785Imported, ERS007670_01204Imported, ERS007679_01045Imported, ERS007681_00627Imported, ERS013471_00506Imported, ERS023446_00958Imported, ERS024276_01813Imported, ERS027659_00081Imported, ERS075361_02538Imported, ERS094182_03476Imported, F6W99_03814Imported, FRD82_07080Imported, GJE03_05870Imported, SAMEA2683035_02628Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000388593 Componenti: Chromosome
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 2773Beta_HSDInterPro annotationAdd BLAST260

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107RYV Bacteria
COG0451 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002225 3Beta_OHSteriod_DH/Estase
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01073 3Beta_HSD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045K7Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRMGDASL TTELGRVLVT GGAGFVGANL VTTLLDRGHW VRSFDRAPSL
60 70 80 90 100
LPAHPQLEVL QGDITDADVC AAAVDGIDTI FHTAAIIELM GGASVTDEYR
110 120 130 140 150
QRSFAVNVGG TENLLHAGQR AGVQRFVYTS SNSVVMGGQN IAGGDETLPY
160 170 180 190 200
TDRFNDLYTE TKVVAERFVL AQNGVDGMLT CAIRPSGIWG NGDQTMFRKL
210 220 230 240 250
FESVLKGHVK VLVGRKSARL DNSYVHNLIH GFILAAAHLV PDGTAPGQAY
260 270 280 290 300
FINDAEPINM FEFARPVLEA CGQRWPKMRI SGPAVRWVMT GWQRLHFRFG
310 320 330 340 350
FPAPLLEPLA VERLYLDNYF SIAKARRDLG YEPLFTTQQA LTECLPYYVS
360 370
LFEQMKNEAR AEKTAATVKP
Length:370
Mass (Da):40,742
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2A93EC32AFEEA0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000047 Genomic DNA Translation: CFE36892.1
CNCN01000406 Genomic DNA Translation: CKO61761.1
CNFT01000009 Genomic DNA Translation: CKQ76030.1
CQAC01000019 Genomic DNA Translation: CNG87810.1
CQGE01000013 Genomic DNA Translation: CNM66843.1
CQQC01000031 Genomic DNA Translation: CNU16869.1
CQPL01000180 Genomic DNA Translation: CNU27426.1
CQPW01000098 Genomic DNA Translation: CNU27779.1
CQTT01000008 Genomic DNA Translation: CNY12678.1
CSAD01000101 Genomic DNA Translation: COV10480.1
CVKR01000032 Genomic DNA Translation: CRF28004.1
CP044345 Genomic DNA Translation: QEX92993.1
CP045962 Genomic DNA Translation: QGK78370.1
CP046529 Genomic DNA Translation: QGV20818.1
QSXJ01001108 Genomic DNA Translation: REM59759.1
FPTZ01000018 Genomic DNA Translation: SGI02565.1
SRLI01000019 Genomic DNA Translation: TGE03268.1
VOOQ01000162 Genomic DNA Translation: TXB94072.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45462; AMC45462; RN05_1186
CFE36892; CFE36892; ERS007681_00627
CKO61761; CKO61761; ERS024276_01813
CKQ76030; CKQ76030; ERS027659_00081
CKQ89592; CKQ89592; ERS027644_00091
CKR28931; CKR28931; ERS027653_01023
CKS24859; CKS24859; ERS027652_02935
CKV96351; CKV96351; ERS031537_03571
CNH22888; CNH22888; ERS124361_03169
CNM66843; CNM66843; ERS023446_00958
CNU16869; CNU16869; ERS007661_00195
CNU27426; CNU27426; ERS007670_01204
CNU27779; CNU27779; ERS007665_00785
CNY12678; CNY12678; ERS013471_00506
COV10480; COV10480; ERS007679_01045
CRH12927; CRH12927; BN1213_02075
CRH13808; CRH13808; BN1303_02310

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.1984

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000047 Genomic DNA Translation: CFE36892.1
CNCN01000406 Genomic DNA Translation: CKO61761.1
CNFT01000009 Genomic DNA Translation: CKQ76030.1
CQAC01000019 Genomic DNA Translation: CNG87810.1
CQGE01000013 Genomic DNA Translation: CNM66843.1
CQQC01000031 Genomic DNA Translation: CNU16869.1
CQPL01000180 Genomic DNA Translation: CNU27426.1
CQPW01000098 Genomic DNA Translation: CNU27779.1
CQTT01000008 Genomic DNA Translation: CNY12678.1
CSAD01000101 Genomic DNA Translation: COV10480.1
CVKR01000032 Genomic DNA Translation: CRF28004.1
CP044345 Genomic DNA Translation: QEX92993.1
CP045962 Genomic DNA Translation: QGK78370.1
CP046529 Genomic DNA Translation: QGV20818.1
QSXJ01001108 Genomic DNA Translation: REM59759.1
FPTZ01000018 Genomic DNA Translation: SGI02565.1
SRLI01000019 Genomic DNA Translation: TGE03268.1
VOOQ01000162 Genomic DNA Translation: TXB94072.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45462; AMC45462; RN05_1186
CFE36892; CFE36892; ERS007681_00627
CKO61761; CKO61761; ERS024276_01813
CKQ76030; CKQ76030; ERS027659_00081
CKQ89592; CKQ89592; ERS027644_00091
CKR28931; CKR28931; ERS027653_01023
CKS24859; CKS24859; ERS027652_02935
CKV96351; CKV96351; ERS031537_03571
CNH22888; CNH22888; ERS124361_03169
CNM66843; CNM66843; ERS023446_00958
CNU16869; CNU16869; ERS007661_00195
CNU27426; CNU27426; ERS007670_01204
CNU27779; CNU27779; ERS007665_00785
CNY12678; CNY12678; ERS013471_00506
COV10480; COV10480; ERS007679_01045
CRH12927; CRH12927; BN1213_02075
CRH13808; CRH13808; BN1303_02310
PATRICifig|1773.211.peg.1984

Phylogenomic databases

eggNOGiENOG4107RYV Bacteria
COG0451 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR002225 3Beta_OHSteriod_DH/Estase
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01073 3Beta_HSD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045K7Q6_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045K7Q6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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