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Entry version 61 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein

mRNA interferase

Gene

mazF6

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Toxic component of a type II toxin-antitoxin (TA) system.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease
Biological processToxin-antitoxin systemARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
mRNA interferaseUniRule annotation (EC:3.1.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mazF6Imported
ORF Names:DSI38_16965Imported, E5M52_12100Imported, ERS007657_03036Imported, ERS007661_02571Imported, ERS007663_01893Imported, ERS007665_02110Imported, ERS007670_01315Imported, ERS007679_03397Imported, ERS007681_02519Imported, ERS007688_02478Imported, ERS007703_01098Imported, ERS007720_00640Imported, ERS007722_02010Imported, ERS007741_00093Imported, ERS013471_01528Imported, ERS023446_00805Imported, ERS024276_03019Imported, ERS027646_03667Imported, ERS027659_03473Imported, ERS027661_03075Imported, ERS075361_02220Imported, ERS094182_02450Imported, F9908_16620Imported, FRD82_03685Imported, SAMEA2683035_03029Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000041288 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000321489 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PemK/MazF family.UniRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003477, PemK-like
IPR011067, Plasmid_toxin/cell-grow_inhib

The PANTHER Classification System

More...
PANTHERi
PTHR33988, PTHR33988, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02452, PemK_toxin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF033490, MazF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045JJA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVISRAEIYW ADLGPPSGSQ PAKRRPVLVI QSDPYNASRL ATVIAAVITS
60 70 80 90 100
NTALAAMPGN VFLPATTTRL PRDSVVNVTA IVTLNKTDLT DRVGEVPASL
110
MHEVDRGLRR VLDL
Length:114
Mass (Da):12,262
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59A18C54B9EDDBCE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000339 Genomic DNA Translation: CFE40460.1
CFOH01000418 Genomic DNA Translation: CFE55822.1
CGCX01001335 Genomic DNA Translation: CFR92950.1
CNCN01000943 Genomic DNA Translation: CKP55990.1
CNFU01000746 Genomic DNA Translation: CKS43695.1
CNFT01001009 Genomic DNA Translation: CKS71426.1
CNGE01000907 Genomic DNA Translation: CKT48669.1
CQAC01000015 Genomic DNA Translation: CNG78432.1
CQGE01000011 Genomic DNA Translation: CNM61427.1
CQPL01000202 Genomic DNA Translation: CNU33462.1
CQPV01000256 Genomic DNA Translation: CNU83065.1
CQPW01000412 Genomic DNA Translation: CNV07098.1
CQQC01000931 Genomic DNA Translation: CNV51131.1
CQTT01000031 Genomic DNA Translation: CNY41731.1
CSAE01000084 Genomic DNA Translation: COV30899.1
CHKL01000004 Genomic DNA Translation: COV52476.1
CSAJ01000050 Genomic DNA Translation: COV64763.1
CSAM01000132 Genomic DNA Translation: COW19959.1
CSAD01000611 Genomic DNA Translation: COW21818.1
CVKR01000018 Genomic DNA Translation: CRF27003.1
WFKV01000022 Genomic DNA Translation: KAB7800544.1
QSXJ01001036 Genomic DNA Translation: REM63780.1
FPTZ01000024 Genomic DNA Translation: SGI19075.1
SRLJ01000024 Genomic DNA Translation: TGD75938.1
VOOQ01000069 Genomic DNA Translation: TXB94713.1

NCBI Reference Sequences

More...
RefSeqi
WP_003410010.1, NZ_WUJD01000025.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC46406; AMC46406; RN05_2130
CFE40460; CFE40460; ERS007681_02519
CFE55822; CFE55822; ERS007688_02478
CFR92950; CFR92950; ERS007657_03036
CFS31069; CFS31069; ERS007734_00351
CKO27231; CKO27231; ERS024213_00177
CKP55990; CKP55990; ERS024276_03019
CKQ78574; CKQ78574; ERS027652_00086
CKQ80635; CKQ80635; ERS027656_00009
CKQ86509; CKQ86509; ERS027654_00205
CKQ90397; CKQ90397; ERS027644_00107
CKS43695; CKS43695; ERS027661_03075
CKS71426; CKS71426; ERS027659_03473
CKS80819; CKS80819; ERS027666_01625
CKT48669; CKT48669; ERS027646_03667
CKU09186; CKU09186; ERS027653_04854
CKV12453; CKV12453; ERS031537_02001
CNH07444; CNH07444; ERS124361_02764
CNM61427; CNM61427; ERS023446_00805
CNU33462; CNU33462; ERS007670_01315
CNU83065; CNU83065; ERS007663_01893
CNV07098; CNV07098; ERS007665_02110
CNV51131; CNV51131; ERS007661_02571
CNY41731; CNY41731; ERS013471_01528
COV26522; COV26522; ERS007672_01440
COV30899; COV30899; ERS007703_01098
COV52476; COV52476; ERS007741_00093
COV64763; COV64763; ERS007720_00640
COW19959; COW19959; ERS007722_02010
COW21818; COW21818; ERS007679_03397
COW25508; COW25508; ERS007726_00417
COW71033; COW71033; ERS007728_00554
COW91650; COW91650; ERS007731_01119
CRH10299; CRH10299; BN1303_00593
CRH10660; CRH10660; BN1213_00807

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23491831

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.466

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000339 Genomic DNA Translation: CFE40460.1
CFOH01000418 Genomic DNA Translation: CFE55822.1
CGCX01001335 Genomic DNA Translation: CFR92950.1
CNCN01000943 Genomic DNA Translation: CKP55990.1
CNFU01000746 Genomic DNA Translation: CKS43695.1
CNFT01001009 Genomic DNA Translation: CKS71426.1
CNGE01000907 Genomic DNA Translation: CKT48669.1
CQAC01000015 Genomic DNA Translation: CNG78432.1
CQGE01000011 Genomic DNA Translation: CNM61427.1
CQPL01000202 Genomic DNA Translation: CNU33462.1
CQPV01000256 Genomic DNA Translation: CNU83065.1
CQPW01000412 Genomic DNA Translation: CNV07098.1
CQQC01000931 Genomic DNA Translation: CNV51131.1
CQTT01000031 Genomic DNA Translation: CNY41731.1
CSAE01000084 Genomic DNA Translation: COV30899.1
CHKL01000004 Genomic DNA Translation: COV52476.1
CSAJ01000050 Genomic DNA Translation: COV64763.1
CSAM01000132 Genomic DNA Translation: COW19959.1
CSAD01000611 Genomic DNA Translation: COW21818.1
CVKR01000018 Genomic DNA Translation: CRF27003.1
WFKV01000022 Genomic DNA Translation: KAB7800544.1
QSXJ01001036 Genomic DNA Translation: REM63780.1
FPTZ01000024 Genomic DNA Translation: SGI19075.1
SRLJ01000024 Genomic DNA Translation: TGD75938.1
VOOQ01000069 Genomic DNA Translation: TXB94713.1
RefSeqiWP_003410010.1, NZ_WUJD01000025.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC46406; AMC46406; RN05_2130
CFE40460; CFE40460; ERS007681_02519
CFE55822; CFE55822; ERS007688_02478
CFR92950; CFR92950; ERS007657_03036
CFS31069; CFS31069; ERS007734_00351
CKO27231; CKO27231; ERS024213_00177
CKP55990; CKP55990; ERS024276_03019
CKQ78574; CKQ78574; ERS027652_00086
CKQ80635; CKQ80635; ERS027656_00009
CKQ86509; CKQ86509; ERS027654_00205
CKQ90397; CKQ90397; ERS027644_00107
CKS43695; CKS43695; ERS027661_03075
CKS71426; CKS71426; ERS027659_03473
CKS80819; CKS80819; ERS027666_01625
CKT48669; CKT48669; ERS027646_03667
CKU09186; CKU09186; ERS027653_04854
CKV12453; CKV12453; ERS031537_02001
CNH07444; CNH07444; ERS124361_02764
CNM61427; CNM61427; ERS023446_00805
CNU33462; CNU33462; ERS007670_01315
CNU83065; CNU83065; ERS007663_01893
CNV07098; CNV07098; ERS007665_02110
CNV51131; CNV51131; ERS007661_02571
CNY41731; CNY41731; ERS013471_01528
COV26522; COV26522; ERS007672_01440
COV30899; COV30899; ERS007703_01098
COV52476; COV52476; ERS007741_00093
COV64763; COV64763; ERS007720_00640
COW19959; COW19959; ERS007722_02010
COW21818; COW21818; ERS007679_03397
COW25508; COW25508; ERS007726_00417
COW71033; COW71033; ERS007728_00554
COW91650; COW91650; ERS007731_01119
CRH10299; CRH10299; BN1303_00593
CRH10660; CRH10660; BN1213_00807
GeneIDi23491831
PATRICifig|1773.211.peg.466

Family and domain databases

Gene3Di2.30.30.110, 1 hit
InterProiView protein in InterPro
IPR003477, PemK-like
IPR011067, Plasmid_toxin/cell-grow_inhib
PANTHERiPTHR33988, PTHR33988, 1 hit
PfamiView protein in Pfam
PF02452, PemK_toxin, 1 hit
PIRSFiPIRSF033490, MazF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045JJA9_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045JJA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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