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Entry version 62 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

HTH-type transcriptional regulator

Gene

sinR

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HTH-type transcriptional regulatorImported
Submitted name:
Helix-turn-helix domain-containing proteinImported
Submitted name:
Helix-turn-helix transcriptional regulatorImported
Submitted name:
Transcriptional regulatorImported
Submitted name:
XRE family transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sinRImported
ORF Names:AYJ03_002485Imported, DSI38_20185Imported, E5M05_01335Imported, ERS007657_01428Imported, ERS007661_01462Imported, ERS007663_00784Imported, ERS007665_02539Imported, ERS007670_02153Imported, ERS007679_03173Imported, ERS007681_01664Imported, ERS007688_01656Imported, ERS007703_04991Imported, ERS007722_00689Imported, ERS007741_01897Imported, ERS013471_01919Imported, ERS023446_00709Imported, ERS024276_00424Imported, ERS027646_00868Imported, ERS027659_03065Imported, ERS027661_00689Imported, ERS075361_01806Imported, ERS094182_00210Imported, F6W99_03131Imported, FRD82_20005Imported, GJE03_02480Imported, SAMEA2683035_00949Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000041288 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000388593 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000321489 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 80HTH cro/C1-typeInterPro annotationAdd BLAST55

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105MDD Bacteria
COG1396 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00093 HTH_XRE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR010982 Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01381 HTH_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00530 HTH_XRE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47413 SSF47413, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50943 HTH_CROC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045J2Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEEKLAAK VSTKASDVAS DIGSFIRSQR ETAHVSMRQL AERSGVSNPY
60 70 80 90 100
LSQVERGLRK PSADVLSQIA KALRVSAEVL YVRAGILEPS ETSQVRDAII
110 120 130 140
TDTAITERQK QILLDIYASF THQNEATREE CPSDPTPTDD
Length:140
Mass (Da):15,364
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2B1694ED778DB93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000178 Genomic DNA Translation: CFE39285.1
CFOH01000224 Genomic DNA Translation: CFE50167.1
CGCX01000441 Genomic DNA Translation: CFR76112.1
CNCN01000057 Genomic DNA Translation: CKN79352.1
CNFU01000092 Genomic DNA Translation: CKR15328.1
CNGE01000103 Genomic DNA Translation: CKR88152.1
CNFT01000828 Genomic DNA Translation: CKS41147.1
CQAC01000011 Genomic DNA Translation: CNG64789.1
CQGE01000009 Genomic DNA Translation: CNM57751.1
CQPV01000081 Genomic DNA Translation: CNU23215.1
CQPL01000424 Genomic DNA Translation: CNU87194.1
CQQC01000409 Genomic DNA Translation: CNU98604.1
CQPW01000551 Genomic DNA Translation: CNV28794.1
CQTT01000046 Genomic DNA Translation: CNY54625.1
CSAM01000030 Genomic DNA Translation: COV73222.1
CSAD01000533 Genomic DNA Translation: COW12057.1
CHKL01000187 Genomic DNA Translation: COW23260.1
CSAE01001065 Genomic DNA Translation: COX26514.1
CVKR01000002 Genomic DNA Translation: CRF24799.1
CP044345 Genomic DNA Translation: QEX92324.1
CP045962 Genomic DNA Translation: QGK77783.1
CP046529 Genomic DNA Translation: QGV20227.1
QSXJ01001061 Genomic DNA Translation: REM62181.1
FPTZ01000004 Genomic DNA Translation: SGH35363.1
SRLI01000002 Genomic DNA Translation: TGE07386.1
VOOQ01000801 Genomic DNA Translation: TXB91642.1

NCBI Reference Sequences

More...
RefSeqi
WP_003402335.1, NZ_WJSJ01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC44780; AMC44780; RN05_0504
CFE39285; CFE39285; ERS007681_01664
CFE50167; CFE50167; ERS007688_01656
CFR76112; CFR76112; ERS007657_01428
CKN79352; CKN79352; ERS024276_00424
CKQ91608; CKQ91608; ERS027653_00326
CKQ94465; CKQ94465; ERS027652_00389
CKR05526; CKR05526; ERS027656_00502
CKR15328; CKR15328; ERS027661_00689
CKR40960; CKR40960; ERS027654_01281
CKR88152; CKR88152; ERS027646_00868
CKS16129; CKS16129; ERS027644_02666
CKS41147; CKS41147; ERS027659_03065
CKT25054; CKT25054; ERS027666_02413
CNG08458; CNG08458; ERS124361_00139
CNM57751; CNM57751; ERS023446_00709
CNU23215; CNU23215; ERS007663_00784
CNU87194; CNU87194; ERS007670_02153
CNU98604; CNU98604; ERS007661_01462
CNV28794; CNV28794; ERS007665_02539
CNY54625; CNY54625; ERS013471_01919
COU59405; COU59405; ERS007672_00001
COV73222; COV73222; ERS007722_00689
COW12057; COW12057; ERS007679_03173
COW23260; COW23260; ERS007741_01897
COX24820; COX24820; ERS007731_01685
COX26514; COX26514; ERS007703_04991
CRH13899; CRH13899; BN1213_02520
CRH16538; CRH16538; BN1303_03714

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.4086

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000178 Genomic DNA Translation: CFE39285.1
CFOH01000224 Genomic DNA Translation: CFE50167.1
CGCX01000441 Genomic DNA Translation: CFR76112.1
CNCN01000057 Genomic DNA Translation: CKN79352.1
CNFU01000092 Genomic DNA Translation: CKR15328.1
CNGE01000103 Genomic DNA Translation: CKR88152.1
CNFT01000828 Genomic DNA Translation: CKS41147.1
CQAC01000011 Genomic DNA Translation: CNG64789.1
CQGE01000009 Genomic DNA Translation: CNM57751.1
CQPV01000081 Genomic DNA Translation: CNU23215.1
CQPL01000424 Genomic DNA Translation: CNU87194.1
CQQC01000409 Genomic DNA Translation: CNU98604.1
CQPW01000551 Genomic DNA Translation: CNV28794.1
CQTT01000046 Genomic DNA Translation: CNY54625.1
CSAM01000030 Genomic DNA Translation: COV73222.1
CSAD01000533 Genomic DNA Translation: COW12057.1
CHKL01000187 Genomic DNA Translation: COW23260.1
CSAE01001065 Genomic DNA Translation: COX26514.1
CVKR01000002 Genomic DNA Translation: CRF24799.1
CP044345 Genomic DNA Translation: QEX92324.1
CP045962 Genomic DNA Translation: QGK77783.1
CP046529 Genomic DNA Translation: QGV20227.1
QSXJ01001061 Genomic DNA Translation: REM62181.1
FPTZ01000004 Genomic DNA Translation: SGH35363.1
SRLI01000002 Genomic DNA Translation: TGE07386.1
VOOQ01000801 Genomic DNA Translation: TXB91642.1
RefSeqiWP_003402335.1, NZ_WJSJ01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC44780; AMC44780; RN05_0504
CFE39285; CFE39285; ERS007681_01664
CFE50167; CFE50167; ERS007688_01656
CFR76112; CFR76112; ERS007657_01428
CKN79352; CKN79352; ERS024276_00424
CKQ91608; CKQ91608; ERS027653_00326
CKQ94465; CKQ94465; ERS027652_00389
CKR05526; CKR05526; ERS027656_00502
CKR15328; CKR15328; ERS027661_00689
CKR40960; CKR40960; ERS027654_01281
CKR88152; CKR88152; ERS027646_00868
CKS16129; CKS16129; ERS027644_02666
CKS41147; CKS41147; ERS027659_03065
CKT25054; CKT25054; ERS027666_02413
CNG08458; CNG08458; ERS124361_00139
CNM57751; CNM57751; ERS023446_00709
CNU23215; CNU23215; ERS007663_00784
CNU87194; CNU87194; ERS007670_02153
CNU98604; CNU98604; ERS007661_01462
CNV28794; CNV28794; ERS007665_02539
CNY54625; CNY54625; ERS013471_01919
COU59405; COU59405; ERS007672_00001
COV73222; COV73222; ERS007722_00689
COW12057; COW12057; ERS007679_03173
COW23260; COW23260; ERS007741_01897
COX24820; COX24820; ERS007731_01685
COX26514; COX26514; ERS007703_04991
CRH13899; CRH13899; BN1213_02520
CRH16538; CRH16538; BN1303_03714
PATRICifig|1773.206.peg.4086

Phylogenomic databases

eggNOGiENOG4105MDD Bacteria
COG1396 LUCA

Family and domain databases

CDDicd00093 HTH_XRE, 1 hit
Gene3Di1.10.260.40, 1 hit
InterProiView protein in InterPro
IPR001387 Cro/C1-type_HTH
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF01381 HTH_3, 1 hit
SMARTiView protein in SMART
SM00530 HTH_XRE, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS50943 HTH_CROC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045J2Q6_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045J2Q6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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