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Entry version 62 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

HTH-type transcriptional regulator

Gene

ttgR

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi40 – 59H-T-H motifPROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HTH-type transcriptional regulatorImported
Submitted name:
TetR family transcriptional regulatorImported
Submitted name:
TetR/AcrR family transcriptional regulatorImported
Submitted name:
Transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ttgRImported
ORF Names:AYJ03_018005Imported, DSI38_22000Imported, E5M05_19940Imported, ERS007657_00065Imported, ERS007665_00332Imported, ERS007670_00204Imported, ERS007679_00702Imported, ERS007681_02240Imported, ERS007688_02869Imported, ERS007741_01336Imported, ERS013471_03633Imported, ERS023446_03071Imported, ERS024276_00478Imported, ERS027646_00843Imported, ERS027659_01787Imported, ERS027661_00140Imported, ERS075361_03414Imported, ERS094182_03630Imported, F6W99_02069Imported, GJE03_17910Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000048948 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000388593 Componenti: Chromosome
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 77HTH tetR-typeInterPro annotationAdd BLAST61

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023772 DNA-bd_HTH_TetR-type_CS
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00440 TetR_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00455 HTHTETR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01081 HTH_TETR_1, 1 hit
PS50977 HTH_TETR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045I830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTRPATDRR KMPTGREEVA AAILQAATDL FAERGPAATS IRDIAARSKV
60 70 80 90 100
NHGLVFRHFG TKDQLVGAVL DHLGTKLTRL LHSEAPADII ERALDRHGRV
110 120 130 140 150
LARALLDGYP VGQLQQRFPN VAELLDAVRP RYDSDLGARL AVAHALALQF
160 170 180
GWRLFAPMLR SATGIDELTG DELRLSVNDA VARILEPH
Length:188
Mass (Da):20,609
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B226876C5A43630
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000279 Genomic DNA Translation: CFE39851.1
CFOH01000537 Genomic DNA Translation: CFE60403.1
CGCX01000011 Genomic DNA Translation: CFR64570.1
CNCN01000065 Genomic DNA Translation: CKN81776.1
CNFU01000013 Genomic DNA Translation: CKQ83359.1
CNFT01000360 Genomic DNA Translation: CKR58720.1
CNGE01000099 Genomic DNA Translation: CKR86955.1
CQAC01000032 Genomic DNA Translation: CNH15999.1
CQGE01000083 Genomic DNA Translation: CNN35142.1
CQPL01000023 Genomic DNA Translation: CNT79534.1
CQPW01000035 Genomic DNA Translation: CNU06797.1
CQTT01000156 Genomic DNA Translation: CNZ13748.1
CSAD01000060 Genomic DNA Translation: COU94984.1
CHKL01000113 Genomic DNA Translation: COW05598.1
CVKR01000035 Genomic DNA Translation: CRF28154.1
CP044345 Genomic DNA Translation: QEX91275.1
CP045962 Genomic DNA Translation: QGK80503.1
CP046529 Genomic DNA Translation: QGV22986.1
QSXJ01001081 Genomic DNA Translation: REM61242.1
SRLI01000059 Genomic DNA Translation: TGD97501.1

NCBI Reference Sequences

More...
RefSeqi
WP_003417984.1, NZ_WJSJ01000068.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC47898; AMC47898; RN05_3622
CFE39851; CFE39851; ERS007681_02240
CFE60403; CFE60403; ERS007688_02869
CFR64570; CFR64570; ERS007657_00065
CKN81776; CKN81776; ERS024276_00478
CKQ83359; CKQ83359; ERS027661_00140
CKR28177; CKR28177; ERS024213_04699
CKR48618; CKR48618; ERS027653_01426
CKR58720; CKR58720; ERS027659_01787
CKR73863; CKR73863; ERS027644_01983
CKR76535; CKR76535; ERS027656_02038
CKR86955; CKR86955; ERS027646_00843
CKR88273; CKR88273; ERS027652_02392
CKS69475; CKS69475; ERS027666_01449
CKU89098; CKU89098; ERS031537_01478
CNG93096; CNG93096; ERS124361_02342
CNN35142; CNN35142; ERS023446_03071
CNT79534; CNT79534; ERS007670_00204
CNU06797; CNU06797; ERS007665_00332
CNZ13748; CNZ13748; ERS013471_03633
COU94984; COU94984; ERS007679_00702
COV30772; COV30772; ERS007672_01539
COW05598; COW05598; ERS007741_01336
CRH11574; CRH11574; BN1213_01310
CRH16163; CRH16163; BN1303_03528

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.2613

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000279 Genomic DNA Translation: CFE39851.1
CFOH01000537 Genomic DNA Translation: CFE60403.1
CGCX01000011 Genomic DNA Translation: CFR64570.1
CNCN01000065 Genomic DNA Translation: CKN81776.1
CNFU01000013 Genomic DNA Translation: CKQ83359.1
CNFT01000360 Genomic DNA Translation: CKR58720.1
CNGE01000099 Genomic DNA Translation: CKR86955.1
CQAC01000032 Genomic DNA Translation: CNH15999.1
CQGE01000083 Genomic DNA Translation: CNN35142.1
CQPL01000023 Genomic DNA Translation: CNT79534.1
CQPW01000035 Genomic DNA Translation: CNU06797.1
CQTT01000156 Genomic DNA Translation: CNZ13748.1
CSAD01000060 Genomic DNA Translation: COU94984.1
CHKL01000113 Genomic DNA Translation: COW05598.1
CVKR01000035 Genomic DNA Translation: CRF28154.1
CP044345 Genomic DNA Translation: QEX91275.1
CP045962 Genomic DNA Translation: QGK80503.1
CP046529 Genomic DNA Translation: QGV22986.1
QSXJ01001081 Genomic DNA Translation: REM61242.1
SRLI01000059 Genomic DNA Translation: TGD97501.1
RefSeqiWP_003417984.1, NZ_WJSJ01000068.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC47898; AMC47898; RN05_3622
CFE39851; CFE39851; ERS007681_02240
CFE60403; CFE60403; ERS007688_02869
CFR64570; CFR64570; ERS007657_00065
CKN81776; CKN81776; ERS024276_00478
CKQ83359; CKQ83359; ERS027661_00140
CKR28177; CKR28177; ERS024213_04699
CKR48618; CKR48618; ERS027653_01426
CKR58720; CKR58720; ERS027659_01787
CKR73863; CKR73863; ERS027644_01983
CKR76535; CKR76535; ERS027656_02038
CKR86955; CKR86955; ERS027646_00843
CKR88273; CKR88273; ERS027652_02392
CKS69475; CKS69475; ERS027666_01449
CKU89098; CKU89098; ERS031537_01478
CNG93096; CNG93096; ERS124361_02342
CNN35142; CNN35142; ERS023446_03071
CNT79534; CNT79534; ERS007670_00204
CNU06797; CNU06797; ERS007665_00332
CNZ13748; CNZ13748; ERS013471_03633
COU94984; COU94984; ERS007679_00702
COV30772; COV30772; ERS007672_01539
COW05598; COW05598; ERS007741_01336
CRH11574; CRH11574; BN1213_01310
CRH16163; CRH16163; BN1303_03528
PATRICifig|1773.206.peg.2613

Family and domain databases

InterProiView protein in InterPro
IPR023772 DNA-bd_HTH_TetR-type_CS
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS01081 HTH_TETR_1, 1 hit
PS50977 HTH_TETR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045I830_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045I830
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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