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Entry version 62 (07 Oct 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Phenolpthiocerol synthesis type-I polyketide synthase PPSE

Gene

ppsE

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseImported, Multifunctional enzymeARBA annotation, Transferase
Biological processFatty acid metabolismARBA annotation, Lipid metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phenolpthiocerol synthesis type-I polyketide synthase PPSEImported (EC:2.3.1.41Imported)
Submitted name:
Phthiocerol type I polyketide synthase PpsEImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppsEImported
ORF Names:DSI38_07440Imported, E5M52_07060Imported, ERS013471_00232Imported, ERS094182_02276Imported, SAMEA2683035_02330Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000047893 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei965O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A045GQI4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini930 – 1004CarrierInterPro annotationAdd BLAST75

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR032821, KAsynt_C_assoc
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR020801, PKS_acyl_transferase
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR016039, Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF00668, Condensation, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF00550, PP-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827, PKS_AT, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF52151, SSF52151, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045GQI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIPENAIAV VGMAGRFPGA KDVSAFWSNL RRGKESIVTL SEQELRDAGV
60 70 80 90 100
SDKTLADPAY VRRAPLLDGI DEFDAGFFGF PPLAAQVLDP QHRLFLQCAW
110 120 130 140 150
HALEDAGADP ARFDGSIGVY GTSSPSGYLL HNLLSHRDPN AVLAEGLNFD
160 170 180 190 200
QFSLFLQNDK DFLATRISHA FNLRGPSIAV QTACSSSLVA VHLACLSLLS
210 220 230 240 250
GECDMALAGG SSLCIPHRVG YFTSPGSMVS AVGHCRPFDV RADGTVFGSG
260 270 280 290 300
VGLVVLKPLA AAIDAGDRIH AVIRGSAINN DGSAKMGYAA PNPAAQADVI
310 320 330 340 350
AEAHAVSGID SSTVSYVECH GTGTPLGDPI EIQGLRAAFE VSQTSRSAPC
360 370 380 390 400
VLGSVKSNIG HLEVAAGIAG LIKTILCLKN KALPATLHYT SPNPELRLDQ
410 420 430 440 450
SPFVVQSKYG PWECDGVRRA GVSSFGVGGT NAHVVLEEAP AEASEVSAHA
460 470 480 490 500
EPAGPQVILL SAQTAAALGE SRTALAAALE TQDGPRLSDV AYTLARRRKH
510 520 530 540 550
NVTMAAVVHD REHAATVLRA AEHDNVFVGE AAHDGEHGDR ADAAPTSDRV
560 570 580 590 600
VFLFPGQGAQ HVGMAKGLYD TEPVFAQHFD TCAAGFRDET GIDLHAEVFD
610 620 630 640 650
GTATDLERID RSQPALFTVE YALAKLVDTF GVRAGAYIGY STGEYIAATL
660 670 680 690 700
AGVFDLQTAI KTVSLRARLM HESPPGAMVA VALGPDDVTQ YLPPEVELSA
710 720 730 740 750
VNDPGNCVVA GPKDQIRALR QRLTEAGIPV RRVRATHAFH TSAMDPMLGQ
760 770 780 790 800
FQEFLSRQQL RPPRTPLLSN LTGSWMSDQQ VVDPASWTRQ ISSPIRFADE
810 820 830 840 850
LDVVLAAPSR ILVEVGPGGS LTGSAMRHPK WSTTHRTVRL MRHPLQDVDD
860 870 880 890 900
RDTFLRALGE LWSAGVEVDW TPRRPAVPHL VSLPGYPFAR QRHWVEPNHT
910 920 930 940 950
VWAQAPGANN GSPAGTADGS TAATVDAARN GESQTEVTLQ RIWSQCLGVS
960 970 980 990 1000
SVDRNANFFD LGGDSLMAIS IAMAAANEGL TITPQDLYEY PTLASLTAAV
1010 1020 1030 1040 1050
DASFASSGLA KPPEAQANPA VPPNVTYFLD RGLRDTGRCR VPLILRLDPK
1060 1070 1080 1090 1100
IGLPDIRAVL TAVVNHHDAL RLHLVGNDGI WEQHIAAPAE FTGLSNRSVP
1110 1120 1130 1140 1150
NGVAAGSPEE RAAVLGILAE LLEDQTDPNA PLAAVHIAAA HGGPHYLCLA
1160 1170 1180 1190 1200
IHAMVTDDSS RQILATDIVT AFGQRLAGEE ITLEPVSTGW REWSLRCAAL
1210 1220 1230 1240 1250
ATHPAALDTR SYWIENSTKA TLWLADALPN AHTAHPPRAD ELTKLSSTLS
1260 1270 1280 1290 1300
VEQTSELDDG RRRFRRSIQT ILLAALGRTI AQTVGEGVVA VELEGEGRSV
1310 1320 1330 1340 1350
LRPDVDLRRT VGWFTTYYPV PLACATGLGA LAQLDAVHNT LKSVPHYGIG
1360 1370 1380 1390 1400
YGLLRYVYAP TGRVLGAQRT PDIHFRYAGV IPELPSGDAP VQFDSDMTLP
1410 1420 1430 1440 1450
VREPIPGMGH AIELRVYRFG GSLHLDWWYD TRRIPAATAE ALERTFPLAL
1460 1470 1480
SALIQEAIAA EHTEHDDSEI VGEPEAGALV DLSSMDAG
Length:1,488
Mass (Da):158,745
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6418D88A27BB701
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CQTT01000003 Genomic DNA Translation: CNY05377.1
CVKR01000016 Genomic DNA Translation: CRF26830.1
QSXJ01000526 Genomic DNA Translation: REM68134.1
FPTZ01000015 Genomic DNA Translation: SGH92180.1
SRLJ01000012 Genomic DNA Translation: TGD78104.1

NCBI Reference Sequences

More...
RefSeqi
WP_003900602.1, NZ_WUJD01000043.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC47395; AMC47395; RN05_3119
CKQ94543; CKQ94543; ERS027654_00357
CNG67692; CNG67692; ERS124361_01551
CNY05377; CNY05377; ERS013471_00232
CRH11312; CRH11312; BN1303_01042
CRH12433; CRH12433; BN1213_01800

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23490824

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.1104

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CQTT01000003 Genomic DNA Translation: CNY05377.1
CVKR01000016 Genomic DNA Translation: CRF26830.1
QSXJ01000526 Genomic DNA Translation: REM68134.1
FPTZ01000015 Genomic DNA Translation: SGH92180.1
SRLJ01000012 Genomic DNA Translation: TGD78104.1
RefSeqiWP_003900602.1, NZ_WUJD01000043.1

3D structure databases

SMRiA0A045GQI4
ModBaseiSearch...

Genome annotation databases

EnsemblBacteriaiAMC47395; AMC47395; RN05_3119
CKQ94543; CKQ94543; ERS027654_00357
CNG67692; CNG67692; ERS124361_01551
CNY05377; CNY05377; ERS013471_00232
CRH11312; CRH11312; BN1303_01042
CRH12433; CRH12433; BN1213_01800
GeneIDi23490824
PATRICifig|1773.211.peg.1104

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR032821, KAsynt_C_assoc
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR020801, PKS_acyl_transferase
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF00668, Condensation, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF00550, PP-binding, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF52151, SSF52151, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045GQI4_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045GQI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 7, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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