Proteomes · Escherichia coli O6:K15:H31 (strain 536 / UPEC)
- Proteome IDUP000009182
- StatusOther proteome
- Number of entries
- Taxonomy | StrainEscherichia coli O6:K15:H31 (strain 536 / UPEC) | 536 / UPEC
- Genome assembly and annotation
- Genome representationFull
- Pan proteomeThis proteome is part of the Escherichia coli (strain K12) pan proteome (FASTA)
- Completeness (CPD)Close to standard (low value)
- BUSCOSingleDuplicatedFragmentedMissingn:440 · enterobacterales_odb10C:99.1% (S:98.6% D:0.5%) F:0.2% M:0.7%
Description
Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.
The uropathogenic Escherichia coli (UPEC) strain 536 was originally isolated from a patient with acute pyelonephritis. Strain 536 (O6:K15:H31) is one of the model organisms of extraintestinal E. coli. The genome consists of a circular chromosome of 4.9 Mbp, and harbors 5 well characterized pathogenicity islands and a newly identified sixth island, encoding the key virulence factors of this strain. Excision of 4 of the 6 islands was observed. It belongs to phylogroup B2.